Phospho­sphingolipids

We provide MS-based lipid analysis of phosphosphingolipids in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category

About the structure and biological function of Phospho­sphingolipids

Structure. Phosphosphingolipids belong to the sphingolipids. Their structure consists of a ceramide backbone linked to a phosphorylated “head” group, such as phosphorylcholine or phosphorylinositol. The ceramide backbone of phosphosphingolipids contains a hydrocarbon chain termed long-chain base; one fatty acid is linked to the ceramide.

Function. Phosphosphingolipids may be found in some bacteria but are present in most eukaryotes such as animals, plants, and fungi. The specific phosphosphingolipid classes to be found depend on the type of organism. Sphingomyelins (SM) are mainly present in animals where they serve as a major source of ceramides and are vital to the formation of lipid rafts, subdomains of the cell membrane.

Inositolphosphorylceramides (IPC) occur in lipid rafts of plants, fungi, and some bacteria where they replace sphingomyelins. Their mannosyl-glycosylated forms (MIPC and M(IP)2C) are common in yeast and required for membrane protein localization. Ethanolaminephosphorylceramides are the sphingomyelin analogue of insects and some bacteria.

Phospho­sphingolipids lipidomics analysis with Lipotype

Covered classes4
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded

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