About the structure and biological function of oxiOME
Structure. Oxidized octadecaenoic acids (oxiOME) belong to the group of octadecanoids within the fatty acyls. Their structure is based on octadecanoic acid, an eighteen carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains one double bond, from which their name derives. OxiOMEs may further encompass multiple oxygen containing substituents such as hydroxy and epoxy groups.
Function. The biological role of oxidized octadecaenoic acids is associated with modifying inflammatory responses. For example, they increase sensitivity to inflammatory pain. OxiOME synthesis is increased during cold temperatures to stimulate activity of brown adipose tissue and thus body temperature – a mechanism which is also triggered by exercising. Dysregulated oxidized octadecaenoic acids levels have been found in pulmonary diseases such as asthma and chronic obstructive pulmonary disease (COPD).
