Oxidized Octadeca­enoic Acid

We provide MS-based lipid analysis of oxiOME fatty acyls in a variety of sample types and deliver results in eight or less weeks.

Details

Fatty Acyls
Lipid Category
Octadecanoids
Lipid Group

About the structure and biological function of oxiOME

Structure. Oxidized octadecaenoic acids (oxiOME) belong to the group of octadecanoids within the fatty acyls. Their structure is based on octadecanoic acid, an eighteen carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains one double bond, from which their name derives. OxiOMEs may further encompass multiple oxygen containing substituents such as hydroxy and epoxy groups.

Function. The biological role of oxidized octadecaenoic acids is associated with modifying inflammatory responses. For example, they increase sensitivity to inflammatory pain. OxiOME synthesis is increased during cold temperatures to stimulate activity of brown adipose tissue and thus body temperature – a mechanism which is also triggered by exercising. Dysregulated oxidized octadecaenoic acids levels have been found in pulmonary diseases such as asthma and chronic obstructive pulmonary disease (COPD).

oxiOME lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified < 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time8 weeks
Lipidomics datapmol & mol%
Figuresin development

EXAMPLE STRUCTURE
oxiOME

An example for the molecular structure of 9,10-epoxy-12-octadecaenoic acid.

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