About the structure and biological function of oxiHTrE
Structure. Oxidized heptadecatrienoic acids (oxiHTrE) belong to the group of heptadecanoids within the fatty acyls. Their structure is based on heptadecanoic acid, a seventeen carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains three double bonds, from which their name derives. OxiHTrE may further encompass multiple hydroxy groups as well as other oxygen containing substituents.
Function. Heptadecatrienoic acids are a diverse class of lipids yet their biological roles are not well known. The oxiHTrE lipids 12-HHT and 12-KHT both bind to the BLT2 receptor, which is involved in cell migration and inflammatory responses and crucial for maintaining intestinal barrier function and skin wound healing. The 12-HHT/12-KHT-BLT2 axis is researched as a promising target for treating inflammatory diseases such as asthma or psoriasis.
