Largest skin lipidomics study provides a basis for
personalized cosmetics

The largest lipidomics study to date analyzing skin lipids in more than 250 skin samples has been published in “Scientific Reports” (Sadowski T. et al. “Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry.” Scientific Reports 2017, doi: 10.1038/srep43761). The study applied a novel Skin Lipidomics Technology Platform developed by Lipotype GmbH, a German Max-Planck-Institute spin-off. Results showed that the skin lipidome varies with respect to sampling depth, site, age and subject. This variation seems to be driven, mainly by secretion of sebaceous lipids and this finding could have an intriguing impact on the design of cosmetic products. Results also reveal a high inter-individual variation of the lipid profile of each person, which could become the basis for the development of personalized cosmetics.  Read more


Discover how skin lipidomics can be applied for your research and product development and get the White Paper.


Meet us at in-cosmetics in London (04th -06th of April 2017): Schedule an individual appointment

 

Meet the Lipotype team until summer 2017!

30.-31. March 2017
Workshop on the Role of Lipids in Autophagy, Copenhagen, Denmark
This workshop will take place at the Danish Cancer Society Research Center in Copenhagen. Prof. Kai Simons, Founder and CEO of Lipotype, will hold a presentation about ‘Lipidrafts to clinical Lipidomics’. We hope he will have some fruitful discussions.

 

04.-06. April 2017
in-cosmetics global, London, UK
Dr. Oliver Uecke and Tomasz Sadowski will participate to find new cooperation partners and customers to inform about our novel skin Lipidomics for cosmetic and dermatological applications.

If you want to schedule an individual meeting drop us a line

 

05.-06. April 2017
Deutsche Biotechno- logietage, Hannover, Germany
Dr. Christian Klose, Head of R&D, will participate and talk about Innovative Lipid Analysis for Cosmetics and Dermatology Applications on the second day of the conference.

 

16.-18. May 2017
Biotechnica 2017, Hannover, Germany
Meet the Lipotype team at their booth at Biotechnica 2017 in the Innovation Zone where we inform you about our Shotgun Lipidomics Technology. 

 


 

Lipotype is sponsoring the following Events:

26. February -02. March 2017
Keystone Symposia, California, USA
Lipidomics and Bioactive Lipids in Metabolism and Disease (B6)

 

10.-12. May 2017
36th Summer Symposium in Molecular Biology, Pennsylvania, USA
Metabolism: Disease Models and Model Organisms

 

Two publications of researchers at the
Flanders Institute of Biotechnology (VIB)
with Lipotype lipidomics

Lipotype Shotgun Lipidomics coupled with the novel superparamagnetic nanoparticles-based organelle purification uncovers lipid composition of plasma membrane and endosomes in storage disorder diseases.

A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency – Scientific Reports, 2017
Arun K. Tharkeshwar, Jesse Trekker, Wendy Vermeire, Jarne Pauwels, Ragna Sannerud, David A. Priestman, Danielle te Vruchte, Katlijn Vints, Pieter Baatsen, Jean-Paul Decuypere, Huiqi Lu, Shaun Martin, Peter Vangheluwe, Johannes V. Swinnen, Liesbet Lagae, Francis Impens, Frances M. Platt, Kris Gevaert, Wim Annaert 


Lipotype Shotgun Lipidomics applied to mitochondria helps to link the lipid metabolism with the electron transport via action of phosphatase and tensin homologue–induced kinase (PINK1), a protein associated with Parkinson’s disease.

Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency – The Journal of Cell Biology, 2017
Melissa Vos, Ann Geens, Claudia Böhm, Liesbeth Deaulmerie, Jef Swerts, Matteo RossiKatleen Craessaerts, Elvira P. Leites, Philip Seibler, Aleksandar Rakovic, Thora Lohnau, Bart De Strooper, Sarah-Maria Fendt, Vanessa A. Morais, Christine Klein, Patrik Verstreken


Read more about research at VIB: http://www.vib.be

 

Launch of BEAt-DKD

An Innovative Medicines Initiative (IMI) Project for Precision Medicine in Diabetic Kidney Disease

with Lipotype as project partner

 

BEAt-DKD (“Biomarker Enterprise to Attack Diabetic Kidney Disease”), a unique public private partnership funded by the Innovative Medicines Initiative (IMI), member companies from the European Federation of Pharmaceutical Industries and Associations (EFPIA), the Juvenile Diabetes Research Foundation (JDRF) and the state of Switzerland has announced the launch of a 5-­­year project (total budget 28.9 Million Euro) with the aim to improve prevention and management of Diabetes Kidney Disease (DKD).

Leading experts from 21 academic institutions, 6 EFPIA pharmaceutical companies, 1 biotech company and JDRF launched BEAt-DKD to provide a holistic systems medicine view of the pathogenesis and heterogeneity of DKD, with the goal to identify targetable mechanisms and pathways underlying initiation and progression of DKD, as well as to identify and validate biomarkers of disease progression and treatment responses, representing first steps towards precision medicine in DKD. Lipotype is project partner in this consortium.

Please download the official press release of the BEAt-DKD consortium here

Lipotype measures lipidomes
for protein-lipid interaction study

Zhou et al. show that K-Ras C-terminal membrane anchor encodes an previously unsuspected anionic lipid binding specificity, which is realized by defined conformational structures of the anchor. Subtle changes to anchor sequence or prenylation profoundly alter its lipid specificity and is a key determinant of K-Ras signal output.

Lipotype is proud of its contribution to this exciting study.

Read the whole publication here:

Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output – Cell, 2017
Yong Zhou, Priyanka Prakash, Hong Liang, Kwang-Jin Cho, Alemayehu A. Gorfe, John F. Hancock

Have you purchased all your presents for the Holiday Season?

WHY NOT A LIPID ANALYSIS PACKAGE FOR THE HOLIDAYS?

Lipotype lipid analysis on sale: 10% off for every package ordered until 15.01.2017

Use the promotional code:

»lipidomics-for-holidays«

in our webshop and order your lipid analysis today.

Join the lipid revolution!

Merry Christmas and a peaceful Holiday Season
Your Lipotype Team

Lipotype and Lund University publish about lipid profiles in Diabetes and infarction

In the latest issue of the Journal of the American Heart Association, Lipotype and Lund University published a paper in which high-throughput lipidomic screening was successfully applied to reveal molecular lipid profiles in blood serum specific for Diabetes mellitus and myocardial infarction.

Read the whole publication here:

Identification of Shared and Unique Serum Lipid Profiles in Diabetes Mellitus and Myocardial Infarction, , 2016
Sanela Kjellqvist, Christian Klose, Michal A. Surma, George Hindy, Inês G. Mollet, Anna Johansson, Patrick Chavaux, Johan Gottfries, Kai Simons, Olle Melander and Céline Fernandez

 

robert_koch_medal_gold_medal_161103.jpg

Robert Koch Gold Medal 2016 to Kai Simons

Press release

Berlin/Dresden, 4 November 2016: Kai Simons, founding director of the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and managing director of Lipotype GmbH, receives the Robert Koch Medal in Gold for his lifetime achievements, in particular for his characterization of membrane-forming lipids and the development of the lipid raft concept. The Award Ceremony takes place on Friday, November 4th 2016 at the Berlin-Brandenburg Academy of Sciences and Humanities.


Read the full press release here

 Open PDF: EnglishDeutsch

 Download Microsoft Word File: English / Deutsch

 

Picture of the award ceremony

picture-kai-robert-koch-award

During the award ceremony at the Berlin-Brandenburg Academy of Sciences and Humanities, Kai Simons received the award from Annette Widmann-Mauz, Parliamentary State Secretary, and Dr. Hubertus Erlen, Chairman of the Board of Directors of the Robert Koch Foundation.

Photo: David Ausserhofer

Novel skin lipidomics for cosmetic
and dermatological applications

Lipotype GmbH, a German Max-Planck spin-off company, launched its novel Lipotype Shotgun Skin Lipidomics Technology and offers lipid analysis services for applications such as cosmetic claim support, topical drug development, efficacy testing for dermatological pharmacology and the cosmetic industry.

High-throughput skin lipidomics with ultra-broad fully quantitative coverage
Until recently, investigating skin lipidomes was not a trivial task. On one hand, the analytical method needs to have coverage broad enough to encompass the variety of skin lipids, and a throughput allowing for statistically relevant studies. On the other hand the method should be compatible with a convenient sampling technique such as tape stripping. These prerequisites are now met in the Lipotype Shotgun Skin Lipidomics Technology platform as explained by Prof. Kai Simons, CEO of Lipotype: “We offer unprecedented throughput of hundreds of samples, absolutely quantified with broad coverage of ceramides, triglycerides and other lipids, and this is all available for samples collected by super-easy tape stripping.” The development of Lipotype Skin Lipidomics was supported by the German Central Innovation Programme for SMEs.

Applications of skin lipidomics
With tools such as Lipotype Skin Lipidomics it is now easy to investigate how the healthy skin lipidome is composed, how it changes in diseases or upon intervention with a drug or a cosmetic product. This lipidomic data can be used for cosmetic claim support, topical drug development and efficacy testing. “We are excited about new possibilities to include skin lipidomics in the product development process of cosmetics companies as well as for biomarker identification for dermatology”, says Dr. Oliver Uecke, Head of Business Development and Finance at Lipotype GmbH.

Read the full press release here
Open Adobe PDF Version
 Download the Microsoft Word Version


Meet us at cosmetics360 in Paris (13.-14.10.2016)

Schedule an individual appointment and  contact us


“HIGHLIGHTS” of our novel Lipotype Shotgun Skin Lipidomics Technology

Read more here


 

Follow us on LinkedIn, Twitter or subscribe to our newsletter

Meet the LIPOTYPE team until the end of 2016

12.-13. October 2016
Cosmetics 360, Paris, France
Dr. Oliver Uecke and Tomasz Sadowski will participate cosmetics 360 to find new cooperation partners and to inform about our novel skin Lipidomics for cosmetic and dermatological applications

 

18. October 2016
Bionection 2016, Halle, Germany
Meet us at the partnering conference for technology transfer in life sciences and have a chat with Dr. Oliver Uecke, Head of BD and Finance about our recent projects and latest news.

 

20.-21. October 2016
VIB – life science research institute, Ghent and Leuven, Belgium
Meet Dr. Oliver Uecke and our scientist Dr. Christian Klose for a scientific talk held in Ghent on the 20th of October at 2pm and in Leuven on the 21st of October at 9:30am. They will inform you how Lipidomics could strengthen your research.

 

27.-29. October 2016
Lipotype is a spin-off company from the MPI-CBG. You will meet Prof. Kai Simons, CEO of Lipotype and founding director of the MPI-CBG as well as Lipotype team members who were trained at the MPI-CBG. Dr. Christian Klose, Head of R&D will give a flash talk. We’re looking forward to catch up with old colleagues and to grow our network – Join the lipid revolution!

 

3. November 2016
Charité Berlin, Germany
Meet Lipotype’s scientist Dr. Christian Klose at the Campus Carité Mitte of Charité Univeristätsmedizin Berlin who will inform you about our ‘Lipotype Shotgun Lipidomics technology for quantitative high throughput lipid analysis’ in a scientific talk. The talk will be held at 2pm at the Center for Cardiovascular Research. 

 

13.-15. November 2016
Lipidomics Forum 2016, Dortmund, Germany
We will be poster price sponsor of this important lipidomics event in Germany. Dr. Ronny Herzog will announce the winner for the best poster on the last conference day, the 15th of November at 12:30pm.

 

29.-30. November 2016
6th Biomarker Conference, Munich, Germany
Dr. Christian Klose will attend the Conference and will give a presentation about Lipidomic parameters associated with obesity at the 29th of November at 5.45 pm.

 

03.-07. December 2016
ASCB 2016,
San Francisco, USA
We are exhibitor at the Conference. Please come and visit us at our booth 1100 to talk to our scientists.

Or attend when Dr. Christian Klose gives a Techtalk on the 6th of December at 8:15am about Lipotype Shotgun Lipidomics technology for quantitative high throughput lipid analysis located in Theater 2.