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Galactosylsphingosine

We provide MS-based lipid analysis of GalSph sphingolipids in a variety of sample types and deliver results in six or less weeks.

Details

Sphingolipids
Lipid Category
Sphingoid Bases
Lipid Group

About the structure and biological function of GalSph

Structure. Galactosylsphingosines (galactosyl-sphing-4-enines, psychosines, or GalSph) belong to the group of sphingoid bases within the sphingolipids. Their structure consists of an amino alcohol with a monounsaturated hydrocarbon chain linked to a galactose molecule.

Function. Galactosylsphingosines are enriched in sensory neurons of the skin and can cause itching by activating specific receptors. They accumulate in Krabbe disease, a genetic lysosomal storage disorder which results in degeneration of oligodendrocytes. GalSph have been linked to lysosomal membrane permeabilization and thus lysosome-dependent cell death and further to stimulation of the immune system as well as bone resorption.

GalSph lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified < 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time6 weeks
Lipidomics datapmol & mol%
Figuresincluded

EXAMPLE STRUCTURE
GalSph

An example for the molecular structure of galactosylsphingosine, specifically GalSph.

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    Friedrich Miescher Institute
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    KU Leuven
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    DSM Skin Biology
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