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We provide MS-based lipid analysis of GalSph sphingolipids in a variety of sample types and deliver results in six or less weeks.


Lipid Category
Sphingoid Bases
Lipid Group

About the structure and biological function of GalSph

Structure. Galactosylsphingosines (galactosyl-sphing-4-enines, psychosines, or GalSph) belong to the group of sphingoid bases within the sphingolipids. Their structure consists of an amino alcohol with a monounsaturated hydrocarbon chain linked to a galactose molecule.

Function. Galactosylsphingosines are enriched in sensory neurons of the skin and can cause itching by activating specific receptors. They accumulate in Krabbe disease, a genetic lysosomal storage disorder which results in degeneration of oligodendrocytes. GalSph have been linked to lysosomal membrane permeabilization and thus lysosome-dependent cell death and further to stimulation of the immune system as well as bone resorption.

GalSph lipidomics analysis with

Structural detailsmolecular species
Variants identified < 10
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Delivery time6 weeks
Lipidomics datapmol & mol%


An example for the molecular structure of galactosylsphingosine, specifically GalSph.


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    Aldeyra Therapeutics
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    Friedrich Miescher Institute
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    KU Leuven
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    DSM Skin Biology
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    University of Alberta
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