Tag Press Release

Lipotype is GMP certified!

Good Manufacturing Practices (GMP) ensure safety and quality of pharmaceutical products. Lipotype is the worldwide first and only officially GMP certified shotgun lipidomics service provider for pharmaceutical applications.


The need for GMP regulations
Quality variations can pose direct threats to patient health – especially in the pharma industry. This is why quality control plays a central role in manufacturing and developing pharmaceutical products. GMP certifications are issued by governmental authorities to ensure product quality and compliance with mandatory health agency requirements.

As worldwide first and only shotgun lipidomics service provider with official GMP certificate by state authority, Lipotype now offers untargeted, global and absolutely quantitative lipidomics analysis services according to GMP regulation laid down in Directive 2003/94/EC.


GMP-compliant lipidomics services
Pharma researchers challenging therapeutic limitations by developing new pharmaceutical products can draw on Lipotype Shotgun Lipidomics services beyond lipidomic analysis of content, purity and stability. Development of GMP compliant analytical tests and release analysis of compounds from clinical trials to market release complete the portfolio of GMP certified lipid analysis services.


Resources

Press Release: Worldwide first and only shotgun lipidomics service provider with official GMP certificate


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New method for molecular profiling of adipose tissue

The Paul Langerhans Institute Dresden, a partner of the DZD, and the University Hospital Carl Gustav Carus joined their forces with Lipotype GmbH and developed a new shotgun lipidomics method for the molecular profiling of brown and white adipose tissue. The results of this collaborative work have now been published in the journal ́Molecular Metabolism ́.


To better understand adipose tissue
Adipose tissue consists of more than 99% of storage lipids, mainly triglycerides that are stored within the cell in so-called lipid droplets. Nonetheless, the remaining 0.5-1% of lipids are sufficient to build a metabolically active cell in all its complexity.

Despite the enormous importance of adipose tissue in human health and diseases (like diabetes), no standardized method existed so far, to quantitatively and reproducibly analyze its lipidome. Thus, Paul Langerhans Institute Dresden (PLID), German Center for Diabetes Research (DZD), the Institute for Clinical Chemistry and Laboratory Medicine of the University Hospital Carl Gustav Carus Dresden (IKL) and Lipotype GmbH chose to tackle this urgent need. Their joint vision of an omics-driven clinic, fueled the development of a shotgun lipidomics protocol for adipose tissue.


A new protocol
This new and validated protocol wants to facilitate the systematic molecular profiling of adipose tissue by providing high reproducibility and linear dynamic range for all lipid classes. Besides covering all types of adipose tissue, it can be used for fatty organs, and can be integrated with further omics approaches used in pre-clinical research.


Resources

Press Release: Dresden scientists develop new shotgun lipidomics method for molecular profiling of adipose tissue


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Lipotype launches first global Lipidomics Excellence Award

Lipotype announces LEA, the Lipidomics Excellence Award, for breakthrough lipidomics projects. Call for applications is open till March 30, 2019.


LEA at a glance
LEA has been created to promote, support and strengthen researchers who are eager to contribute to the progress of life sciences through lipidomics.

Up to three individuals with ongoing research are awarded with comprehensive research prizes to support their projects. Applications are open to all researchers who are eager to strengthen life sciences through lipidomics.

The awardees are selected by a panel composed of internationally renown members of academia, each of them recognized as leading experts in their respective fields.

LEA is supported by LIPID MAPS, SwissLipids and Lipotype.


The first prize
The winner of the first prize will receive 55,000 EUR worth of analysis services in order to put their idea to test. The awardee will be presenting their research at an internationally leading experts summit for lipids and lipidomics, the EMBO Workshop “Lipid function in health and disease” in Dresden (Sept 27th – 30th, 2019). A press conference will be held to present the project and formally handover the LEA 2019 trophy.


How to apply
Individual researchers from academia and industry and their ongoing projects can apply for LEA 2019. Applicants are asked to outline their idea for a project or research approach whose results they think can be boosted by a detailed lipid analysis. All applications shall be submitted until March 30, 2019 via the online submission form.


Resources

Press Release: Lipotype Launches first global Lipidomics Excellence Award – ENG
Press Release: Lipotype startet den ersten weltweiten Lipidomics Excellence Award – DEU
Online Submission Form


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Lipotype presents the awardees of the Lipidomics Forum 2018

We proudly present the winners of best poster and best scientific talk award at the Lipidomics Forum 2018.


A short history of the Lipidomics Forum
The Lipidomics Forum is a joint effort of the ISAS Dortmund and the Research Center Borstel. The annual symposium is a series of conferences on lipid biology and lipidomics to provide a platform for international acknowledged scientists, students, and young researchers to interact. It does not only cover current research highlights but also offers tutorials on selected methodical topics.

The Lipidomics Forum has become a home for Lipotype. Besides a shared scientific background, we strive for the same goals such as global scientific excellence and exchange. This is why Lipotype began attending and supporting through awards the conference many years ago.


The awardees
The best poster award was won by Bing Peng (middle). She researches blood platelets and their lipid composition which is critical for platelet integrity and functionality. She could show, that the lipidome changes upon platelet activation. Congrats, Bing Peng!

The best scientific talk award was won by Marcus Höring (right). His work aims at the intestinal lipid metabolism and the influence of gut microbia. He made use of isotope labeled fatty acids to achieve that. Congrat, Marcus Höring!

Ronny Herzog
Dr. Ronny Herzog, Head of Software Development and IT-Infrastructure, and the awardees.

Dominik Schwudke (top left) and Robert Ahrends (bottom left) have been organizing the Lipidomics Forum since its beginning. To say thank you, we gifted both a rafting weekend. We are certain, they will have as much fun as we have with our lipid raft.


Resources

Press Release: Lipotype presents the awardees of the Lipidomics Forum 2018

Abstract book of the Lipidomics Forum 2018

Lipidomics Forum 2018


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New White Paper “Unlocking the Power of Multiomics”

Multiomics approaches harness synergies and eliminate shortcomings to effectively deliver what one omics science alone cannot achieve. Lipotype’s new white paper “Unlocking the Power of Multiomics” highlights why combining genomics with lipidomics makes for a great omics pair.


Genomics for genes, lipidomics for lipids
Being major players in cardiovascular disease research, genomics and lipidomics are perfectly suited for a joint multiomics approach. It matches the capacity to identify genetic predestinations with one or multiple snapshots of the lipid metabolic status.

Linking genotype with phenotype will be critical when it comes to clinical diagnostics and to the goal of identifying the onsets of a disease.


From genotype to phenotype: interconnected disease risk factors
In this study, a large number of SNPs (single-nucleotide polymorphisms) from genomes was drawn. They were then correlated with corresponding lipid species levels from human blood plasma. The blood plasma has been analyzed with Lipotype Shotgun Lipidomics technology. The most important findings are the following.

First, the heritability of lipid species levels was quantified from the SNP correlations. Second, genetic predispositions influencing lipid species levels provide useful information for cardiovascular disease risk predictions. And third, lipidomics yields greater statistical power to identify SNPs with direct roles in lipid metabolism. Lipidomics outperforms traditional lipid panel measures used in clinical routine.


Resources

Lipotype White Paper: Unlocking the Power of Multiomics

Press release: Unlocking the Power of Multiomics – Lipotype releases new Multiomics White Paper


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Press Release: Lipotype and Lipoid celebrate their joint IFSCC 2018 Poster Success

Lipotype and Lipoid presented a joint poster featuring the core findings of their skin lipidome research at IFSCC 2018 in Munich. Overwhelmingly positive feedback resulted in placing the poster among the top 10 of all IFSCC 2018 posters.


A successful congress and a great poster
The International Federation of Societies of Cosmetic Chemists is dedicated to international cooperation in cosmetic science and technology. This year’s congress was about “Cosmetics: Science for Beauty and Lifestyle”.

Lipotype and Lipoid chose the IFSCC to present their findings as the congress focuses on exploring what modern society wants from cosmetics and dermatology. This represents both companies’ consumer oriented research best, which was confirmed on-site by the great feedback of those who visited the poster. Ultimately, the IFSCC committee chose to rank the joint poster of Lipotype and Lipoid among the top 10 of all IFSCC 2018 posters.


The project in short
Lipoid conducted this novel study to investigate skin penetration properties of dermal formulations based on hydrogenated phospholipids. For the first time, the quantitative analysis of both exogenous phospholipids and endogenous skin lipids within a single measurement was demonstrated. The results confirm the properties of hydrogenated phospholipids to penetrate and accumulate in upper epidermal layers. Based on these findings, Lipoid will conduct further investigations to improve delivery and fixation of cosmetic actives.


About Lipoid
Founded over 40 years ago, Lipoid is leading in the development and industrial production of high quality lecithin and phospholipids not only for the pharmaceutical, but also for the cosmetic and dietetic industry. Lipoid is the only company worldwide offering the whole range of natural and synthetic phospholipids in industrial scale. Environmental protection and sustainability determines the company’s strategy within all phases of the value chain. This long-standing expertise, in combination with the exceptional quality of the products enables the customers to develop and market innovative products for the benefit of the general public.


Resources

Press release: IFSCC 2018 poster success – Joint poster selected Top 10 of all IFSCC posters

IFSCC 2018 poster: The effect of saturated phospholipids on human skin as assessed by shotgun lipidomic analysis

IFSCC 2018 poster ranking

Customer reference: Lipid analysis for skin penetration properties of saturated phospholipids


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Lipotype’s customer Lyomark Pharma announces partnership

Lyomark Pharma, a customer of Lipotype, announces a partnership with Aerogen Pharma to develop an inhaled surfactant for the treatment of preterm infants with Respiratory Distress Syndrome (RDS). At the same time clinical trials with the new delivery system have been initiated and the first patients have been recruited. Read more in the press release of Lyomark and Aerogen:


Read more in the press release of Lyomark and Aerogen here:
Aerogen Pharma and Lyomark Pharma partner to develop inhaled surfactant, begin a Phase 2 clinical trial

Lipidomics paves the way to groundbreaking scientific discoveries

VIB’s Technology Watch team has been active for almost a decade, continuously analyzing the potential of emerging technologies and mediating researchers’ access to them. By expanding VIB’s network of technology suppliers, purchasing licenses and negotiating business partnerships, the Tech Watch team enables VIB scientists to have privileged access to cutting-edge scientific innovations. One example comes in the form of a powerful lipidomics research tool made available to VIB scientists through a collaboration with Lipotype, a Max-Planck spin-off and key service provider. Since 2015, Lipotype technology has been a crucial factor in several major breakthroughs in multiple life sciences domains.

The benefits of a dedicated lipidomics collaborator
Lipidomics, or the analysis, identification and quantification of lipids, has important applications in basic and clinical research, as well as in the nutrition, cosmetics and personalized healthcare industries. Using Lipotype’s Shotgun Lipidomics Technology, researchers can rapidly analyze large samples at reasonable prices, benefiting from the ultra-broad coverage and absolute quantification of lipids enabled by this technology.

Mark Veugelers (VIB Tech Watch): “The Tech Watch team, in close collaboration with VIB group leaders, is constantly on the lookout for new technologies that can have a major impact on our research. The Lipidomics services Lipotype offers is a good example. But identification of a novel technology with potential isn’t enough to produce breakthrough results. Key in the process is the hands-on experience of VIB scientists when evaluating the potential of these novel technology opportunities.

Oliver Uecke (Lipotype): “Tech Watch at VIB is a fantastic instrument to support technology transfer.  It’s a win-win situation for all parties involved: VIB researchers get access to innovative technologies early on, while technology providers have the tech watch team as single entry point to address the VIB collective of researchers. VIB profits from providing their researchers with means to generate cutting edge research results and with an improved basis for licensing and spin-off creation.”

Better tech integration, impactful results
After just two years of collaboration, VIB scientists working with Lipotype have published three papers in high-impact academic journals. This demonstrates the fact that partnerships between VIB and specialized tech service providers and the integration of new innovations into VIB research leads to more and faster discoveries.

Prof. Wim Annaert (VIB-KU Leuven): “Lipotype’s Shotgun technology was critical to our recent paper on a new approach to analyzing subcellular dysfunction. Our next challenge is now to integrate lipidomics with proteomics data to better understand what goes on at the level of a single subcellular compartment for instance in a disease context.”
(relevant publication: A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency, Tharkeshwar et al., Scientific Reports 2017)

Prof. Patrik Verstreken (VIB-KU Leuven): “My team recently made groundbreaking discoveries related to mitochondrial defects in Parkinson’s Disease. Tech Watch – and access to Lipotype tech in particular – were essential to these findings.”
(relevant publication: Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency, Vos et al., J Cell Biol 2017)

Prof. Rose Goodchild (VIB-KU Leuven): “Tech Watch funding significantly boosted our confidence in collaborating with Lipotype for our work on cellular lipid metabolism. Lipidomics is a key emerging technology that we don’t have in-house, and our access to it – especially when it comes to molecular and cellular research – adds huge value to our projects.”
(relevant publication: Torsins Are Essential Regulators of Cellular Lipid Metabolism, Gonzalez et al., Developmental Cell 2016)

Read the full press release here
 Open Adobe PDF Version
 Download the Microsoft Word Version

 


About Lipotype

Lipotype is a spin-off company from the Kai Simons and Andrej Shevchenko labs of the world-renowned Max-Planck-Institute of Molecular Cell Biology and Genetics in Dresden, Germany. Drawing on many years of cutting edge research experience, Lipotype delivers comprehensive, absolutely quantitative lipid analysis services for clinical and biological samples on a high-throughput scale.

Lipotype offers high quality lipid analysis services for a wide range of customers and applications including biomarker identification for clinical researchers, pharma and biotech companies, functional food development for the food industry, as well as for the small-scale profiling needs of academic researchers.


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Largest skin lipidomics study provides a basis for personalized cosmetics

The largest lipidomics study to date analyzing skin lipids in more than 250 skin samples has been published in “Scientific Reports” (Sadowski T. et al. “Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry.” Scientific Reports 2017, doi: 10.1038/srep43761). The study applied a novel Skin Lipidomics Technology Platform developed by Lipotype GmbH, a German Max-Planck-Institute spin-off. Results showed that the skin lipidome varies with respect to sampling depth, site, age and subject. This variation seems to be driven, mainly by secretion of sebaceous lipids and this finding could have an intriguing impact on the design of cosmetic products. Results also reveal a high inter-individual variation of the lipid profile of each person, which could become the basis for the development of personalized cosmetics.  Read more


Discover how skin lipidomics can be applied for your research and product development and get the White Paper.


Meet us at in-cosmetics in London (04th -06th of April 2017): Schedule an individual appointment

 

Launch of BEAt-DKD

An Innovative Medicines Initiative (IMI) Project for Precision Medicine in Diabetic Kidney Disease

with Lipotype as project partner

 

BEAt-DKD (“Biomarker Enterprise to Attack Diabetic Kidney Disease”), a unique public private partnership funded by the Innovative Medicines Initiative (IMI), member companies from the European Federation of Pharmaceutical Industries and Associations (EFPIA), the Juvenile Diabetes Research Foundation (JDRF) and the state of Switzerland has announced the launch of a 5-­­year project (total budget 28.9 Million Euro) with the aim to improve prevention and management of Diabetes Kidney Disease (DKD).

Leading experts from 21 academic institutions, 6 EFPIA pharmaceutical companies, 1 biotech company and JDRF launched BEAt-DKD to provide a holistic systems medicine view of the pathogenesis and heterogeneity of DKD, with the goal to identify targetable mechanisms and pathways underlying initiation and progression of DKD, as well as to identify and validate biomarkers of disease progression and treatment responses, representing first steps towards precision medicine in DKD. Lipotype is project partner in this consortium.

Please download the official press release of the BEAt-DKD consortium here