Tag Kai Simons

Prof. Anne-Claude Gavin accepts 1st prize of LEA

The laureate of the world’s first Lipidomics Excellence Award, Prof. Dr. Anne-Claude Gavin from the University of Geneva , uses the analysis technology of Dresden based Lipotype GmbH for the next breakthrough in her lipid transfer research. The biochemist draws the world’s first molecular “map of lipid highways”, she is tracing the ways of lipid transfer between the membranes of body cells.


A map of lipid highways
“Latest research shows that the lipid metabolism plays a major role in the development of diabetes, cancer or Alzheimer’s. Once we have a better understanding of the ways certain lipids cause which effect, we may pave the way for new potential treatment approaches”, the laureate explains her research goal. “Lipidomics helps us answering questions we would not even dare to ask without it. It opens doors that may hold the answer to our civilization diseases.”


Lipidomics in diabetes research
Life science researchers of various disciplines discover Lipotype’s Shotgun Lipidomics Analysis for their projects. So does the diabetes research: “Lipidomics is step by step revealing processes and connections that stay hidden with traditional analysis methods”, says Prof. Dr. Michele Solimena, Professor of Molecular Diabetology, Medical School, TU Dresden, Germany and Director of the Paul Langerhans Institute Dresden, a German Center for Diabetes Research. „In diabetes research we make good progress thanks to lipidomics, e.g. it is now possible to define molecular lipid signatures that tell us about the development of non-diabetic to diabetes type 2 and progression towards diabetes complications.”


Deeper insights into the lipid cosmos
The unique Lipidomics Excellence Award rewards innovation and the drive for novelty in researchers who strike out in a new direction using lipidomics. The winner Prof. Dr. Anne-Claude Gavin’s project idea stood out in a strong competition with numerous international scientists and research teams. Ultimately, a top-class independent jury of renowned lipidomics experts awarded the Geneva-based scientist with the first prize equalizing lipid analyses worth 50,000 EUR.

“We want to shine a light on the fact that lipid analyses really make the difference between research and groundbreaking research: by providing new data one gains an even deeper insight into the lipid cosmos. It is high time to seize the potentials. Let us see what there is still to discover“, says Prof. Dr. Kai Simons, Professor and Director Emeritus at Max-Planck-Institute for Molecular Cell Biology and Genetics Dresden and founder and CEO of Lipotype.


About LEA
LEA, the Lipidomics Excellence Award, promotes researchers who are eager to contribute to the progress of life sciences with generous research prizes. Three individuals with ongoing research are awarded to support their projects. Applications were open to all researchers from academia and industry.

The winner of the first prize received 55,000 EUR worth of analysis services and present their research at the EMBO Workshop “Lipid function in health and disease” (27.-30.09.2019). A press conference was hold to
present the project and formally handover the LEA 2019 trophy.

LEA is supported by LIPID MAPS, SwissLipids and Lipotype, and the media Journal of Lipid Research, LABO and transkript.


Resources

1 – Materials: Additional press material including photos
2 – Website: The winners of LEA 2019
3 – Press Release: Summary of the Lipidomics Excellence Award press talk
4 – Pressemitteilung: Zusammenfassung der “Lipidomics Excellence Award”-Pressekonferenz


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HOW CAN OMIC SCIENCE BE IMPROVED?

Kai Simons, founder and CEO of Lipotype, has been following the development of omic science for decades. His lifelong experience as well as his proficiency in lipids and lipidomics has led him to a detailed review.

The published article “How can Omic Science be improved?” critically analyzes the shortcomings of modern omic science, which yet could not fulfill its promise of a paradigm shift in medicine and biology. Bot, scientific evolution and present challenges of this field of research are taken into account to picture the overall view.

While the article itself focuses on lipidomics, Kai Simon’s field of expertise, all lessons learned can be applied generally to omic science.


Read the full article here:
How can Omic Science be improved? – Proteomics Journal, 2018
Kai Simons

Metabolomics meets systems biology

Read the Technology Feature by SCIENCE about “Big data, big picture: Metabolomics meets systems biology” in which companies and scientists explain how they use metabolomics to understand system biology. Lipotype’s CEO, Kai Simons, explains why lipidomics is an important part of metabolomics and that lipids can be quantified which tells about the state of a cell or tissue:

Click here to read the full article

 

Genetic Testing and Analysis

source: www.sciencemag.org

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Robert Koch Gold Medal 2016 to Kai Simons

Press release

Berlin/Dresden, 4 November 2016: Kai Simons, founding director of the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and managing director of Lipotype GmbH, receives the Robert Koch Medal in Gold for his lifetime achievements, in particular for his characterization of membrane-forming lipids and the development of the lipid raft concept. The Award Ceremony takes place on Friday, November 4th 2016 at the Berlin-Brandenburg Academy of Sciences and Humanities.


Read the full press release here

 Open PDF: EnglishDeutsch

 Download Microsoft Word File: English / Deutsch

 

Picture of the award ceremony

picture-kai-robert-koch-award

During the award ceremony at the Berlin-Brandenburg Academy of Sciences and Humanities, Kai Simons received the award from Annette Widmann-Mauz, Parliamentary State Secretary, and Dr. Hubertus Erlen, Chairman of the Board of Directors of the Robert Koch Foundation.

Photo: David Ausserhofer

robert_koch_medal_gold_160523.jpg

Professor Kai Simons receives the Robert Koch Medal in Gold

Professor Kai Simons, Founding Director of the Max-Planck Institute for Molecular Cell Biology and Genetics (MPI-CBG) and Founder/CEO of Lipotype GmbH receives the Robert Koch Medal in Gold for his impressive lifetime achievements, in particular for his characterization of membrane-forming lipids and the development of the Lipid Raft Model.

The lipid raft model is linked to new therapy approaches, for example in neurological diseases such as Alzheimer’s, in which malfunctions in lipid rafts play a role. Kai Simons also found clear evidence that many viruses – including influenza, Ebola, measles and HI viruses – use lipid rafts to invade their host cells or to leave them again, by encasing themselves with rafts from the cell membrane.

 

About the Robert Koch Foundation

The Robert Koch Foundation is a non-profit foundation dedicated to the promotion of medical progress and is based in Berlin. It promotes basic scientific research in the field of infectious diseases, as well as exemplary projects that address medical and hygienic issues. Patron of the Foundation, which was founded in 1907, is German President Joachim Gauck.

Read the whole press release here (Source: Robert-Koch-Stiftung)

 

Lipotype announces introduction of new service packages and the launch of a webshop

Interview with Professor Kai Simons, CEO and founder of Lipotype regarding the introduction of new service packages and the launch of a webshop in early 2016

 

Q: Professor Simons, why lipidomics at all?

Kai Simons: One class of biomolecules that, for long, remained in the shadow of on-going omics upheaval in biology, were the lipids. The scientific community focused on DNA, RNAs and proteins since these studies promised a shortcut to mechanistic understanding of biological function and homeostasis. Within this context, why care about lipids. They were largely seen as an uninteresting heterogeneous set of molecules having few specific functions.

But this is now changing. Lipids not only form the fluid bilayer of our membranes but they interact with proteins and modulate membrane functions. Membrane lipids behave as collectives, form dynamic platforms (rafts) in cell membranes and are major players in metabolism. Therefore, lipids have to be included in our tool kit. Lipid species diversity will only be understood by including lipidomics technologies in the on-going omics (r)evolution. Until now the lipids were mostly excluded. Lipotype wants to change that!

Q: What is the vision of Lipotype?

Kai Simons: We envision Shotgun Lipidomics as a routine tool in academic research, for the development of functional foods and for clinical diagnostics. Lipidomics represents a quantitative phenotyping tool with incisive multi-parametric resolution. Personalized healthcare will be revolutionized by this new technology. Simply said, our vision and slogan is: Lipidomics for a better life!

Q: And what new does your company Lipotype offer?

Kai Simons: We want to enable every researcher to try out lipidomics. Thus, with several others, we introduced a very price-competitive package in our service portfolio of lipid analysis. With the minimum amount of 900 Euro a customer can get a basic analysis of 6 biological samples, what gives only 150 Euro per sample!

Q: What is unique about Lipotype lipid analysis services?

Kai Simons: Lipotype lipid analyses are high-throughput, with broad coverage of lipids and absolute quantitation of each lipid species. Recently, we published a joint paper with Nestlé Institute of Health Sciences, where we showed that the results generated with Lipotype technology are highly reproducible. We performed a comparison and showed that results obtained completely independently at different sites by different researchers have an average coefficient of variation of less than 15%.

The high quality standards of Lipotype are based on years of research experience from our work at Max-Planck on the role of lipids in cellular processes and on the development of lipidomics technology. We believe that the advantages of our technology are an essential prerequisite for the identification of statistical significant and clinical relevant lipid signatures, which can now be used by our customers.

Q: Lipotype will also introduce a webshop to sell its scientific services. That’s quite new for analytical services. Why did you decide to do that?

Kai Simons: Yes, we believe that introducing the webshop is totally novel in our market segment. The advantages will be obvious to our customers. The different service packages are grasped in a glance, prices are known from the beginning and in overall this provides a convenient way to purchase our services.


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