Tag Academia

Lipidomics of Multiple Sclerosis

In multiple sclerosis (MS), a chronic inflammatory and neurodegenerative disease of the central nervous system, the body attacks the protective myelin sheath of neurons in the brain and the spinal cord. The damaged myelin causes communication problems between the central nervous system and the rest of the body. To this day, there is no cure for MS. Neurobiological researchers believe that MS does not only cause the clinical symptoms we look for as of today but also alters a patient’s lipid metabolism.

read more ➔

Multiomics analysis in CVD research

With an ever-increasing pool of accessible information and new tools to mine huge data sets, biology and medicine are moving from intervention to prevention. Omics sciences such as genomics and lipidomics are strong contributors to this paradigm shift. Being major players in cardiovascular disease research, genomics and lipidomics make a great multiomics pair. It matches the capacity to identify genetic predestinations with one or multiple snapshots of the lipid metabolic status to investigate cardiovascular diseases.

read more ➔

Prof. Anne-Claude Gavin accepts 1st prize of LEA

The laureate of the world’s first Lipidomics Excellence Award, Prof. Dr. Anne-Claude Gavin from the University of Geneva , uses the analysis technology of Dresden based Lipotype GmbH for the next breakthrough in her lipid transfer research. The biochemist draws the world’s first molecular “map of lipid highways”, she is tracing the ways of lipid transfer between the membranes of body cells.

read more ➔

First large-scale study of the genetics of human plasma lipid species

Understanding the genetics of lipid species offers information beyond that provided by routine lipid screening, and can help improve risk prediction and treatment. In the first large-scale study, novel lipid-associated genetic variants were identified, some of which were linked with risk for cardiovascular disease, such as heart attacks and strokes. Lipotype provided the technology to measure these lipids – Lipotype Shotgun Lipidomics.

read more ➔

Parkinson’s Disease, Fruit Flies and Lipotype

What happened

Do fruit flies suffer from Parkinson’s? Not exactly. But patients who suffer from this neurological disease experience disturbed sleep patterns long before motor dysfunctions. This can be modelled in fruit flies. Researchers from the Netherlands and Germany showed that excessive contacts between mitochondria and endoplasmic reticulum in Parkinson’s flies lead to abnormal lipid trafficking. This prevents the release of “sleep” neuropeptides, which affects sleep patterns.

read more ➔