With an ever-increasing pool of accessible information and new tools to mine huge data sets, biology and medicine are moving from intervention to prevention. Omics sciences such as genomics and lipidomics are strong contributors to this paradigm shift. Being major players in cardiovascular disease research, genomics and lipidomics make a great multiomics pair. It matches the capacity to identify genetic predestinations with one or multiple snapshots of the lipid metabolic status to investigate cardiovascular diseases.
A famous malaria treatment has been debated as a medical option in preventive measures against COVID-19. Prominent figures continued to market the malaria medicine as a quick breakthrough to combat the pandemic. However, the debate was fierce from the beginning.
Researchers at Oslo University Hospital applied lipidomics when using lipid metabolism inhibitors and discovered an unexpected modulation of lipid metabolism.
The laureate of the world’s first Lipidomics Excellence Award, Prof. Dr. Anne-Claude Gavin from the University of Geneva , uses the analysis technology of Dresden based Lipotype GmbH for the next breakthrough in her lipid transfer research. The biochemist draws the world’s first molecular “map of lipid highways”, she is tracing the ways of lipid transfer between the membranes of body cells.
The month of August came with a set of newly-published lipidomics publications which made use of Lipotype Shotgun Lipidomics.
Understanding the genetics of lipid species offers information beyond that provided by routine lipid screening, and can help improve risk prediction and treatment. In the first large-scale study, novel lipid-associated genetic variants were identified, some of which were linked with risk for cardiovascular disease, such as heart attacks and strokes. Lipotype provided the technology to measure these lipids – Lipotype Shotgun Lipidomics.
July has been a great month. Three new publications with Lipotype Shotgun Lipidomics technology have been put out, and the Lipidomics Resource Center received its first major update. Read more about this!
Do fruit flies suffer from Parkinson’s? Not exactly. But patients who suffer from this neurological disease experience disturbed sleep patterns long before motor dysfunctions. This can be modelled in fruit flies. Researchers from the Netherlands and Germany showed that excessive contacts between mitochondria and endoplasmic reticulum in Parkinson’s flies lead to abnormal lipid trafficking. This prevents the release of “sleep” neuropeptides, which affects sleep patterns.
Pseudomonas aeruginosa is a multi-drug resistant bacteria, and can cause serious illnesses such as pneumonia or sepsis syndromes. The publication from TU Braunschweig shows that, when grown under unaerobic biofilm conditions, the bacterium produces less of a protein, which binds specifically to the central hub of phospholipid metabolism.