The limited ability of the nervous system to regenerate in demyelinating conditions, such as multiple sclerosis, prevents the restoration of its functionality.
In his webinar, Dr. Mikael Simons discusses data that highlights the significant role of lipid metabolism — specifically, lipid droplet formation and cholesterol efflux — in phagocytes for myelin regeneration. He suggests that targeting the lipid-sensing Triggering Receptor Expressed on Myeloid cells (TREM2) or the nuclear Liver X Receptor (LXR) could be potential therapeutic strategies to enhance tissue regeneration after injury.
You can watch the webinar here:
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