Exosomes are nanometer-sized particles derived from the lipid membranes of cells. They play an integral role in communication between cells and organs in the human body. These particles consist of a lipid shell surrounding cargo, which is delivered to specific sites in the body and alters the function of the recipient cell. Exosome-mediated communication has been implicated in the immune response, cancer, and neurodegeneration.
The reengineered exosomes might deliver a vaccine to stimulate the immune system or a chemotherapy drug to a breast cancer cell but not the surrounding healthy tissue.
As a potential drug delivery vehicle, exosomes offer multiple advantages. The natural cargo of exosomes is diverse and may include nucleic acids, proteins, and/or other biomolecules. This provides flexibility in the choice of therapeutic cargo.
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#exosome #LipidMetabolism #ImmuneResponse #lipidomics
