Tag Customer Reference

Investigation of photodamaged dry facial skin from different ethnic groups

Lipotype put online a new skin lipidomics customer reference with Royal DSM about lipid analysis for the investigation of photodamaged dry facial skin from different ethnic groups.


The project in short
Even though decades of moisturizer development have passed, dry facial skin remains a major concern for consumers. Thus, DSM’s aim was to understand more precisely the underlying biochemistry, particularly of the maturation of the stratum corneum and its relation to facial photodamage, skin pigmentation and ethnicity. In contrast to traditional research of skin analyte composition, a more revolutionary ‘omic’ approach was applied.


What Lipotype did
With its mass spectrometry-based Shotgun Skin Lipidomics technology Lipotype delivered lipid analysis of the ceramidome, the entirety of ceramides. The results precisely highlight changes in ceramide composition and distribution which help to explain the differences in facial skin barrier function, hydration and stratum corneum maturation, but also the skin care need of the differently pigmented skin types.


About DSM
Royal DSM is a purpose-led global science-based company in Nutrition, Health and Sustainable Living. With its innovative business solutions for human nutrition, animal nutrition, personal care and aroma, medical devices, green products and applications, DSM is driving economic prosperity, environmental progress and social advances to create sustainable value. DSM’s purpose is to create brighter lives for people today and generations to come.


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Customer reference Royal DSM: lipid analysis for investigation of photodamaged dry facial skin from different ethnic groups


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lipid analysis for skin penetration properties of saturated phospholipids

Lipotype put online a new skin lipidomics customer reference with Lipoid about lipid analysis for skin penetration properties of saturated phospholipids.


What is skin lipidomics

The physiology of skin derives from its structure and composition of its topmost layer, where cells are glued together by lipids. Their composition is influenced by natural conditions, such as age and gender, but also various diseases. Lipotype Skin Shotgun Lipidomics Technology provides the tools to investigate how the healthy skin lipidome is composed, how it changes in diseases or upon intervention with a drug or a cosmetic product. This lipidomic data can be used for cosmetic claim support, topical drug development and personalized cosmetics.


The project in short

Lipoid conducted this novel study to investigate skin penetration properties of dermal formulations based on hydrogenated phospholipids. Common to all topically used phospholipids is their ability to interact with skin structures and the similarity to epidermal lipids. For the first time, the quantitative analysis of both exogenous phospholipids and endogenous skin lipids within a single measurement was demonstrated. The results confirm the properties of hydrogenated phospholipids to penetrate and accumulate in upper epidermal layers. Lipotype performed lipid analysis of phospholipids of an applied formulation, especially focusing on phosphatidylcholine.


About Lipoid

Phospholipids are widespread functional ingredients, not only in pharmaceutical formulations, but in cosmetic and dietetic products as well. Lipoid was the first to offer a wide variety of phospholipids for use in the production of drug products. Today, the majority of approved drugs containing phospholipids are prepared using raw materials from Lipoid. Based on these findings, Lipoid will conduct further investigations to improve delivery and fixation of an active pharmaceutical ingredient.


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Customer reference Lipoid: lipid analysis for skin penetration properties of saturated phospholipids


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Lipid analysis for early stages of drug discovery: Customer Reference Flagship VentureLabs

Lipotype performed lipid analysis for Flagship VentureLabs with the aim to better understand molecular compositions of chondrisomes, pharmaceutically active derivatives of mitochondria. The research of Flagship VentureLabs is on novel ways of preparation of chondrisomes that have beneficial structural characteristics, yield, concentration, stability, viability, integrity, or function. The lipidomic results facilitated the characterization of isolated chondrisomes in order to evaluate their quality and subsequently were used to file a recently published patent application.

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Read the patent application here
Methods and Compositions of Chondrisomes – United States Patent Application 20170151287, 2017
G A Von Maltzahn, J M Milwid, M Mee, J R Rubens, D Chess, K Trudeau, K Mahdaviani, J Feala