Tag Cosmetics / Dermatology

Dermal drug development for SLS associated ichthyosis

Henri Deda January 8, 2019

Lipotype put online a new biotech & dermatology customer reference with Aldeyra Therapeutics about lipid analysis for topical dermal drug development for the treatment of ichthyosis associated with SLS.

The project in short
Sjögren-Larsson Syndrome (SLS) is a rare inborn error of aldehyde metabolism characterized by severe skin thickening (ichthyosis), retinal disease, and neurological dysfunction. As of today, no therapy that addresses SLS has been approved. Aldeyra Therapeutics has conducted a Phase 2 randomized, parallel-group, double-blind, vehicle-controlled, multi-center clinical trial of topical dermal reproxalap for the treatment of ichthyosis associated with SLS. The results of the trial demonstrated clinically meaningful and statistically significant improvements of SLS skin symptoms of patients after only eight weeks of treatment. A multi-center Phase 3 clinical trial is ongoing.

What Lipotype did
Lipotype Shotgun Skin Lipidomics provided Aldeyra Therapeutics with lipid analysis of skin samples for identification of relevant lipid biomarkers in the Phase 2 clinical trial. Results of the skin lipidomics analysis delivered evidence for a correlation between clinical effects and those skin lipid biomarkers. Consistent with the clinical activity of reproxalap, significant dermal biomarker changes were noted in reproxalap-treated patients but not vehicle-treated patients. Cholesterol, which is significantly elevated in the skin of SLS patients, was reduced in reproxalap-treated patients more than in vehicle-treated patients.

About Aldeyra Therapeutics
Aldeyra Therapeutics is a biotechnology company devoted to improving lives by inventing, developing, and commercializing next-generation medicines that treat immune-mediated and metabolic diseases. Aldeyra’s lead product candidate, reproxalap (formerly called NS2), is a small molecule RASP (Reactive Aldehyde Species) inhibitor in Phase 3 clinical development for the treatment of dry eye disease, allergic conjunctivitis, noninfectious anterior uveitis, and Sjögren-Larsson syndrome. With its focus on a carefully selected range of diseases, Aldeyra Therapeutics is devoted to improving lives through outstanding innovation.

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Customer reference Aldeyra Therapeutics: lipid analysis for topical dermal drug development for the treatment of ichthyosis associated with SLS

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Press Release: Lipotype and Lipoid celebrate their joint IFSCC 2018 Poster Success

Henri Deda October 9, 2018

Lipotype and Lipoid presented a joint poster featuring the core findings of their skin lipidome research at IFSCC 2018 in Munich. Overwhelmingly positive feedback resulted in placing the poster among the top 10 of all IFSCC 2018 posters.

A successful congress and a great poster
The International Federation of Societies of Cosmetic Chemists is dedicated to international cooperation in cosmetic science and technology. This year’s congress was about “Cosmetics: Science for Beauty and Lifestyle”.

Lipotype and Lipoid chose the IFSCC to present their findings as the congress focuses on exploring what modern society wants from cosmetics and dermatology. This represents both companies’ consumer oriented research best, which was confirmed on-site by the great feedback of those who visited the poster. Ultimately, the IFSCC committee chose to rank the joint poster of Lipotype and Lipoid among the top 10 of all IFSCC 2018 posters.

The project in short
Lipoid conducted this novel study to investigate skin penetration properties of dermal formulations based on hydrogenated phospholipids. For the first time, the quantitative analysis of both exogenous phospholipids and endogenous skin lipids within a single measurement was demonstrated. The results confirm the properties of hydrogenated phospholipids to penetrate and accumulate in upper epidermal layers. Based on these findings, Lipoid will conduct further investigations to improve delivery and fixation of cosmetic actives.

About Lipoid
Founded over 40 years ago, Lipoid is leading in the development and industrial production of high quality lecithin and phospholipids not only for the pharmaceutical, but also for the cosmetic and dietetic industry. Lipoid is the only company worldwide offering the whole range of natural and synthetic phospholipids in industrial scale. Environmental protection and sustainability determines the company’s strategy within all phases of the value chain. This long-standing expertise, in combination with the exceptional quality of the products enables the customers to develop and market innovative products for the benefit of the general public.

Resources

Press release: IFSCC 2018 poster success – Joint poster selected Top 10 of all IFSCC posters

IFSCC 2018 poster: The effect of saturated phospholipids on human skin as assessed by shotgun lipidomic analysis

IFSCC 2018 poster ranking

Customer reference: Lipid analysis for skin penetration properties of saturated phospholipids

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Investigation of photodamaged dry facial skin from different ethnic groups

Henri Deda September 3, 2018

Lipotype put online a new skin lipidomics customer reference with Royal DSM about lipid analysis for the investigation of photodamaged dry facial skin from different ethnic groups.

The project in short
Even though decades of moisturizer development have passed, dry facial skin remains a major concern for consumers. Thus, DSM’s aim was to understand more precisely the underlying biochemistry, particularly of the maturation of the stratum corneum and its relation to facial photodamage, skin pigmentation and ethnicity. In contrast to traditional research of skin analyte composition, a more revolutionary ‘omic’ approach was applied.

What Lipotype did
With its mass spectrometry-based Shotgun Skin Lipidomics technology Lipotype delivered lipid analysis of the ceramidome, the entirety of ceramides. The results precisely highlight changes in ceramide composition and distribution which help to explain the differences in facial skin barrier function, hydration and stratum corneum maturation, but also the skin care need of the differently pigmented skin types.

About DSM
Royal DSM is a purpose-led global science-based company in Nutrition, Health and Sustainable Living. With its innovative business solutions for human nutrition, animal nutrition, personal care and aroma, medical devices, green products and applications, DSM is driving economic prosperity, environmental progress and social advances to create sustainable value. DSM’s purpose is to create brighter lives for people today and generations to come.

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Customer reference Royal DSM: lipid analysis for investigation of photodamaged dry facial skin from different ethnic groups

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lipid analysis for skin penetration properties of saturated phospholipids

Henri Deda June 21, 2018

Lipotype put online a new skin lipidomics customer reference with Lipoid about lipid analysis for skin penetration properties of saturated phospholipids.

What is skin lipidomics

The physiology of skin derives from its structure and composition of its topmost layer, where cells are glued together by lipids. Their composition is influenced by natural conditions, such as age and gender, but also various diseases. Lipotype Skin Shotgun Lipidomics Technology provides the tools to investigate how the healthy skin lipidome is composed, how it changes in diseases or upon intervention with a drug or a cosmetic product. This lipidomic data can be used for cosmetic claim support, topical drug development and personalized cosmetics.

The project in short

Lipoid conducted this novel study to investigate skin penetration properties of dermal formulations based on hydrogenated phospholipids. Common to all topically used phospholipids is their ability to interact with skin structures and the similarity to epidermal lipids. For the first time, the quantitative analysis of both exogenous phospholipids and endogenous skin lipids within a single measurement was demonstrated. The results confirm the properties of hydrogenated phospholipids to penetrate and accumulate in upper epidermal layers. Lipotype performed lipid analysis of phospholipids of an applied formulation, especially focusing on phosphatidylcholine.

About Lipoid

Phospholipids are widespread functional ingredients, not only in pharmaceutical formulations, but in cosmetic and dietetic products as well. Lipoid was the first to offer a wide variety of phospholipids for use in the production of drug products. Today, the majority of approved drugs containing phospholipids are prepared using raw materials from Lipoid. Based on these findings, Lipoid will conduct further investigations to improve delivery and fixation of an active pharmaceutical ingredient.

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Customer reference Lipoid: lipid analysis for skin penetration properties of saturated phospholipids

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Skin lipidomics: a tool for understanding skin aging at the molecular level

Julia Schoener September 11, 2017

Lipotype published in SOFW Journal about skin lipidomics to better understand skin aging

The lipid composition of human skin is essential for its function; however the simultaneous quantification of a wide range of skin lipids, belonging to both stratum corneum and sebum, is not trivial. Recently we developed a new, “shotgun” mass spectrometry-based method characterized by a broad coverage of lipids, absolute quantitation, high reproducibility and high-throughput providing comprehensive insight into skin lipid composition [1].

We applied this method in a large-scale study of natural lipid variability of human skin. In this study we analyzed samples from 104 individuals of both sexes of different ages. We discovered gradual changes in the skin lipidome correlated with age but no sex-specific differences. Our novel method enables detailed and broad insights into skin lipidomes, both in terms of lipidome coverage and sample number. Therefore, skin shotgun lipidomics has the potential to become useful in studies related to skin aging and anti-aging product claims support.

Read more: 
Click her to read the full article in SOFW Journal

Learn more about Lipotype Skin Lipidomics
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[1] Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry – Scientific Reports, 2017
Tomasz Sadowski, Christian Klose, Mathias J. Gerl, Anna Wójcik-Maciejewicz, Ronny Herzog, Kai Simons, Adam Reich, Michal A. Surma

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Largest skin lipidomics study provides a basis for personalized cosmetics

Julia Schoener March 9, 2017

The largest lipidomics study to date analyzing skin lipids in more than 250 skin samples has been published in “Scientific Reports” (Sadowski T. et al. “Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry.” Scientific Reports 2017, doi: 10.1038/srep43761). The study applied a novel Skin Lipidomics Technology Platform developed by Lipotype GmbH, a German Max-Planck-Institute spin-off. Results showed that the skin lipidome varies with respect to sampling depth, site, age and subject. This variation seems to be driven, mainly by secretion of sebaceous lipids and this finding could have an intriguing impact on the design of cosmetic products. Results also reveal a high inter-individual variation of the lipid profile of each person, which could become the basis for the development of personalized cosmetics.  Read more

Discover how skin lipidomics can be applied for your research and product development and get the White Paper.

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Novel skin lipidomics for cosmetic and dermatological applications

Julia Schoener September 22, 2016

Lipotype GmbH, a German Max-Planck spin-off company, launched its novel Lipotype Shotgun Skin Lipidomics Technology and offers lipid analysis services for applications such as cosmetic claim support, topical drug development, efficacy testing for dermatological pharmacology and the cosmetic industry.

High-throughput skin lipidomics with ultra-broad fully quantitative coverage
Until recently, investigating skin lipidomes was not a trivial task. On one hand, the analytical method needs to have coverage broad enough to encompass the variety of skin lipids, and a throughput allowing for statistically relevant studies. On the other hand the method should be compatible with a convenient sampling technique such as tape stripping. These prerequisites are now met in the Lipotype Shotgun Skin Lipidomics Technology platform as explained by Prof. Kai Simons, CEO of Lipotype: “We offer unprecedented throughput of hundreds of samples, absolutely quantified with broad coverage of ceramides, triglycerides and other lipids, and this is all available for samples collected by super-easy tape stripping.” The development of Lipotype Skin Lipidomics was supported by the German Central Innovation Programme for SMEs.

Applications of skin lipidomics
With tools such as Lipotype Skin Lipidomics it is now easy to investigate how the healthy skin lipidome is composed, how it changes in diseases or upon intervention with a drug or a cosmetic product. This lipidomic data can be used for cosmetic claim support, topical drug development and efficacy testing. “We are excited about new possibilities to include skin lipidomics in the product development process of cosmetics companies as well as for biomarker identification for dermatology”, says Dr. Oliver Uecke, Head of Business Development and Finance at Lipotype GmbH.

Read the full press release here
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“HIGHLIGHTS” of our novel Lipotype Shotgun Skin Lipidomics Technology

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