Innate immune memory, or “trained immunity,” is a state in myeloid cells that enhances immune responses, playing a vital role in the body’s defense and being associated with various immune-related diseases.
Scientists showed that externally introduced sphingolipids and the inhibition of enzymes involved in sphingolipid metabolism can affect trained immunity. The research identified that acid ceramidase, an enzyme that converts ceramide to sphingosine, strongly regulates trained immunity.
These findings underline the immune-modulating function of sphingolipids and identify acid ceramidase as a potential therapeutic target for managing innate immune-driven disorders.
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