The biophysical properties of membranes – such as lipid order, membrane fluidity, and composition – play an influential role in cell signaling and function.

We have prepared a case study where we describe different types of T cells, the development of T cells in the thymus, and the effect of altered lipid metabolism on T helper cells’ functioning.

Overall, this study demonstrates that liver X receptor (LXR) activation in T helper cells alters lipid metabolism and, through mechanisms that involve membrane lipid order and subsequent modification of cell signaling and immune function. This finding indicates that LXR may be an effective therapeutic target for diseases that involve aberrant T cell signalings, such as cancers and autoimmune disorders.

Read the case study here: https://www.lipotype.com/lipidomics-resource-center/?q=LXR+directly+regulates+glycosphingolipid

#tCell #tHelper #immunity #immuneResponse #lipidome #lipidMetabolism #lipidomics