Intercellular lipids serve a barrier function in stratum corneum, which is the outermost layer of skin. The amount of transdermal water evaporationdepends on the packing structure of intercellular lipids. This packing structure consists of a mixture of crystals (orthorhombic and hexagonal) and liquid crystals (fluid phase), and their proportion.
Recent study investigates the planar distribution of intercellular lipid structures of stratum corneum cell units. The distribution of domains formed by packing structures and the lipid composition of ceramides was compared in skin with high- or low-transepidermal water loss.
ESI-MS/MS-based shotgun lipidomics analysis showed that the alpha-hydroxyceramide content in the low- and high-transepidermal water loss groups differed regarding the distribution of fatty acid chain lengths.
#StratumCorneum #lipid #skin #lipidomics #MassSpectrometry #LipidMetabolism #TransepidermalWaterLoss #ceramide
