Antibiotics prevent infections from spreading and help the immune system fight off invading pathogens like bacteria. Their wide-spread use comes with a downside: many bacteria evolved strategies to resist antibiotics thus rendering them ineffective.
The multi resistant bacterium P. aeruginosa is equipped with high natural antibiotic resistance and is known to develop further resistances during therapy making it extraordinarily difficult to overcome. P. aeruginosa is a particular threat to immunocompromised patients and individuals with cystic fibrosis are often affected by a persistent infection with the multi resistant bacteria.
Knocking out the protein PA3911 unbalances phospholipid homeostasis and greatly increases susceptibility of P. aeruginosa to many antibiotics, an approach which was discovered and figured out through the combination of research results from antibiotics exposure testing to lipidomics analysis.
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