Most studies on human pancreatic islets use samples obtained from normoglycemic or diseased donors, which cannot accurately describe the molecular changes that occur in pancreatic beta cells as they progress towards deficient insulin secretion in type 2 diabetes (T2D).
To address this limitation, researchers conducted a comprehensive multi-omics analysis of pancreatic islets obtained from metabolically profiled living human donors with varying glycemic levels, from normal to T2D.
It was found that the regulation of islet gene expression is already altered in prediabetic individuals with impaired glucose tolerance, indicating a non-linear trajectory toward T2D. Moreover, through the integration of islet transcriptomics with plasma lipidomics, potential prognostic markers associated with HbA1c levels were identified.
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#diabetes #T2D #lipidomics #LipidMetabolism #pancreas
