The pathogenesis and progression of many tumors, including hematologic malignancies, is highly dependent on enhanced lipogenesis.

The Shotgun mass spectrometry approach was used to identify lipidome patterns in different types of acute myeloid leukemia (AML) with and without karyotype changes. Differences in lipidomes of AML patients with karyotype changes, as compared to AML patients without karyotype change, were detected mostly in ceramide/sphingolipid synthesis. Additionally, a particular karyotype change affected physicochemical membrane properties, related to the alterations in lipid saturation levels.

The detected changes in lipidomes of various AML types improve our understanding of the pathobiochemical pathways involved. Finally, identifying cancer type-specific lipid profiles allows us to monitor and interpret the actual effects of lipid changes, and potential fingerprints of individual tumors to be explored as diagnostic markers.

Discover more here: https://www.lipotype.com/lipidomics-resource-center/?q=acute%20myeloid%20leukemia

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