Impaired lipid metabolism increases the risk for Parkinson’s disease and dementia with Lewy bodies, promoting the aggregation of α-synuclein (αS) by shifting the tetramer-monomer ratio towards monomers. Excess mono- and polyunsaturated fatty acids further contribute to this aggregation.
Researchers used mice models and showed that reducing LIPE, discussed in a previous post, decreased MUFA release from neutral lipid storage, reducing MUFA in phospholipid membranes, with which αS interacts.
The study highlights that regulating fatty acid turnover, specifically by targeting LIPE, could be a promising therapeutic approach for dementia with Lewy bodies and Parkinson’s disease.
Read the full article here:
#research #lipid #lipidomics #LipidMetabolism #lipotype #lipidome #LIPE #Parkinsons
