Recent publication evaluates the mice ganglioside lipidomes in the brain and optical nerves during the developmental stages and adulthood. Additionally, the ganglioside content of mice lacking genes, responsible for ganglioside species synthesis, was analyzed.
The analysis of the mouse brain during development revealed particular gangliosides of lower complexity to be predominant for an early stage of myelination and the almost completed stage of myelination, but not for the adult stage. The species from more complex ganglioside classes with longer carbon chains and more double bonds were preferentially expressed at the adult stage. The gangliosides from the optic nerve expressed similar patterns.
The researchers examined the brain and optic nerve of ganglioside-deficient mice, which expressed a severe neurological deficit, and found distinct differences within particular ganglioside classes. It is however not clear if this drastic neurological phenotype is a result of myelin degeneration or impaired myelin formation.
For more information check:
#lipidomics #lipid #TeamMassSpec #ganglioside
