Last Monday we described different types of T cells, and today we will talk about their development in the thymus.

The development of T cells in the thymus is a complicated topic. We prepared a simplified graphic describing this process. Check it out on our webpage.

Upon their meeting in the thymus, immature T cells and thymic cells interact. In case of no binding to antigen represented on thymic cell surface, T cell with both CD4 and CD8 undergoes apoptosis. In case of the strong binding when T cell has either CD4 or CD8 cells go through further development and mature into T Helper cell (CD4), Cytotoxic T cell (CD8), or a T Regulatory cell (CD8 CD25). CD4 T cells that bypass binding in the thymus eventually develop into T Regulatory cells (CD4 CD25).

More information: https://www.lipotype.com/lipidomics-resource-center/?q=LXR+directly+regulates+glycosphingolipid

#tCells #CD4CD8 #THelper #cytotoxic #thymus #ImmatureTCells #lipidomics