New publication by (tag authors) reports that the composition of the endoplasmic reticulum (ER) membrane influences the process of ER-associated degradation (ERAD) by affecting the extraction of substrates from the membrane.

The study found that an increase in specific very-long-chain ceramides in the ER membrane leads to a higher level of ubiquitinated substrates in the ER membrane and a decrease in extracted substrates in the cytoplasm.

This suggests that ER membrane lipid remodeling can change the activity of ERAD and highlights a previously unknown mechanism in the regulation of ERAD by the lipid composition of cellular membranes.

Read more here: https://www.lipotype.com/lipidomics-resource-center/?q=the%20ERAD%20system

#ceramide #lipid #lipidomics #MassSpectrometry #EndoplasmicReticulum #ERAD #membrane #cytoplasm