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SNPs are genetic variations in just one base pair. For example, most people may have the genetic code GCAACGTTAGA at a specific position but some might feature the genetic sequence GCAGCGTTAGA instead.

Initial analyses showed that single nucleotide polymorphisms – or SNPs, which are common heritable genetic variations – associate with the presence of certain lipid species in the plasma. Specifically, ceramides and lipids containing polyunsaturated fatty acids were highly heritable; phosphatidylinositols were the least heritable.

For example, variants at GLTPD2 were linked to sphingomyelin concentration and thus risk for atherosclerosis; variants at SPTLC3 were shown to regulate total ceramide levels and thus odds for intracerebral hemorrhage; and variants at COL5A1 were associated with phosphatidylcholine level and thus probability of cerebrovascular disease.

More info here: https://www.lipotype.com/lipidomics-applications/multiomics-analysis-in-cardiovascular-disease-research/

#cardiovascular #SNP #sphingomyelin #BloodPlasma #lipid #lipidomics #MassSpectrometry