Oliver Uecke

Posts by Oliver

Launch of BEAt-DKD

An Innovative Medicines Initiative (IMI) Project for Precision Medicine in Diabetic Kidney Disease

with Lipotype as project partner

 

BEAt-DKD (“Biomarker Enterprise to Attack Diabetic Kidney Disease”), a unique public private partnership funded by the Innovative Medicines Initiative (IMI), member companies from the European Federation of Pharmaceutical Industries and Associations (EFPIA), the Juvenile Diabetes Research Foundation (JDRF) and the state of Switzerland has announced the launch of a 5-­­year project (total budget 28.9 Million Euro) with the aim to improve prevention and management of Diabetes Kidney Disease (DKD).

Leading experts from 21 academic institutions, 6 EFPIA pharmaceutical companies, 1 biotech company and JDRF launched BEAt-DKD to provide a holistic systems medicine view of the pathogenesis and heterogeneity of DKD, with the goal to identify targetable mechanisms and pathways underlying initiation and progression of DKD, as well as to identify and validate biomarkers of disease progression and treatment responses, representing first steps towards precision medicine in DKD. Lipotype is project partner in this consortium.

Please download the official press release of the BEAt-DKD consortium here

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Robert Koch Gold Medal 2016 to Kai Simons

Press release

Berlin/Dresden, 4 November 2016: Kai Simons, founding director of the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and managing director of Lipotype GmbH, receives the Robert Koch Medal in Gold for his lifetime achievements, in particular for his characterization of membrane-forming lipids and the development of the lipid raft concept. The Award Ceremony takes place on Friday, November 4th 2016 at the Berlin-Brandenburg Academy of Sciences and Humanities.


Read the full press release here

 Open PDF: EnglishDeutsch

 Download Microsoft Word File: English / Deutsch

 

Picture of the award ceremony

picture-kai-robert-koch-award

During the award ceremony at the Berlin-Brandenburg Academy of Sciences and Humanities, Kai Simons received the award from Annette Widmann-Mauz, Parliamentary State Secretary, and Dr. Hubertus Erlen, Chairman of the Board of Directors of the Robert Koch Foundation.

Photo: David Ausserhofer

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Professor Kai Simons receives the Robert Koch Medal in Gold

Professor Kai Simons, Founding Director of the Max-Planck Institute for Molecular Cell Biology and Genetics (MPI-CBG) and Founder/CEO of Lipotype GmbH receives the Robert Koch Medal in Gold for his impressive lifetime achievements, in particular for his characterization of membrane-forming lipids and the development of the Lipid Raft Model.

The lipid raft model is linked to new therapy approaches, for example in neurological diseases such as Alzheimer’s, in which malfunctions in lipid rafts play a role. Kai Simons also found clear evidence that many viruses – including influenza, Ebola, measles and HI viruses – use lipid rafts to invade their host cells or to leave them again, by encasing themselves with rafts from the cell membrane.

 

About the Robert Koch Foundation

The Robert Koch Foundation is a non-profit foundation dedicated to the promotion of medical progress and is based in Berlin. It promotes basic scientific research in the field of infectious diseases, as well as exemplary projects that address medical and hygienic issues. Patron of the Foundation, which was founded in 1907, is German President Joachim Gauck.

Read the whole press release here (Source: Robert-Koch-Stiftung)

 

Join the lipid revolution! Lipidomics for everybody

Lipids remained in the shadow of the ongoing “omics” upheaval in biology. But this is now changing. It was never so easy for researchers from universities, research institutes and clinics to try out lipidomics. Lipotype enables researchers to integrate lipidomics in their research. Our lipid analysis start with just 150 Euros per sample, are convenient to order via webshop and deliver publication-ready results.

 

Watch the message from Prof. Kai Simons, leader of the Lipotype team: “The fats fell into disgrace.”

 

New lipid analysis packages: The CEO and founder of Lipotype Professor Kai Simons explains: “We want to enable every researcher to try out lipidomics. Thus, we introduced a very price-competitive analytical package in our service portfolio.” For just 150 Euros per sample, customers can get a comprehensive and quantitative lipid analysis of their biological samples.

Webshop for highest convenience and transparence: Today, e-commerce is helping consumers in everyday life to compare and buy products online. To facilitate its services, Lipotype has now introduced a webshop to sell its products. Dr. Oliver Uecke, Head of Business Development and Finance highlights: “The advantages will be obvious to our customers. The different service packages are grasped at a glance, prices are known from the beginning and overall this provides a convenient and transparent way of purchasing our services.”

Novel data report delivers publication-ready results: Presentation of data is key to understanding results. Lipotype introduced a novel tool called “LipotypeZoom” enabling interactive data analysis and visualization as well as generation of publication-ready figures. This service allows scientists to try out lipidomics with minimal effort. We envision Shotgun Lipidomics as a routine tool in academic research.

Lipidomics as part of advanced systems biology: Lipidomics is the large-scale investigation of amounts, structures and functions of the complete set of lipids (the lipidome) in biological systems. Lipidomics includes also interaction between lipids, as well as their interaction with proteins and other metabolites. Modern lipidomics supplies a fully quantitative description of lipidomes down to the level of individual lipid molecules. Lipidomics together with proteomics and genomics provides the “omics” foundation for advanced systems biology.


 

Join the lipid revolution and visit www.lipotype.com/shop

 


About Lipotype

Lipotype is a spin-off company from the Kai Simons and Andrej Shevchenko labs of the world-renowned Max-Planck-Institute of Molecular Cell Biology and Genetics in Dresden, Germany. Drawing on many years of cutting edge research experience, Lipotype delivers comprehensive, absolutely quantitative lipid analysis services for clinical and biological samples on a high-throughput scale.

Lipotype offers high quality lipid analysis services for a wide range of customers and applications including biomarker identification for clinical researchers, pharma and biotech companies, functional food development for the food industry, as well as for the small-scale profiling needs of academic researchers.


Media contact

Oliver Uecke
+49 (0) 351 79653-45
 media@lipotype.com
 www.lipotype.com

Lipotype GmbH
Tatzberg 47
01307 Dresden / Germany

Successful April! — Articles published

Lipotype collaborated with the groups of Pietro DeCamilli (Yale University School of Medicine) and Ilya Levental (University of Texas) and the results of our lipidomics analysis are now part of their freshly published papers in “Nature Cell Biology” and “Biophysical Journal”. Congratulations!

  • Y. Saheki et al.: “Control of plasma membrane lipid homeostasis by the extended synaptotagmins.”  Access to the paper
  • K. Levental et al.: “Polyunsaturated Lipids Regulate Membrane Domain Stability by Tuning Membrane Order”  Access to the paper


Gratulation also to our employee Dr. Mathias Gerl who published an article about: “Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions” in PLOS ONE  Access to the paper

 

In the current issue of Transkript / LABORWELT Dr. Anke Kopacek (DiagnostikNet-BB e.V., Hennigsdorf) wrote an article about: “Automation im Dienste innovativer Diagnostik” (in German). Lipotype is mentioned as an example for a novel high-throughput OMICS technology for lipid biomarker identification.   Access to the article (see p.IV)

Lipotype announces introduction of new service packages and the launch of a webshop

Interview with Professor Kai Simons, CEO and founder of Lipotype regarding the introduction of new service packages and the launch of a webshop in early 2016

 

Q: Professor Simons, why lipidomics at all?

Kai Simons: One class of biomolecules that, for long, remained in the shadow of on-going omics upheaval in biology, were the lipids. The scientific community focused on DNA, RNAs and proteins since these studies promised a shortcut to mechanistic understanding of biological function and homeostasis. Within this context, why care about lipids. They were largely seen as an uninteresting heterogeneous set of molecules having few specific functions.

But this is now changing. Lipids not only form the fluid bilayer of our membranes but they interact with proteins and modulate membrane functions. Membrane lipids behave as collectives, form dynamic platforms (rafts) in cell membranes and are major players in metabolism. Therefore, lipids have to be included in our tool kit. Lipid species diversity will only be understood by including lipidomics technologies in the on-going omics (r)evolution. Until now the lipids were mostly excluded. Lipotype wants to change that!

Q: What is the vision of Lipotype?

Kai Simons: We envision Shotgun Lipidomics as a routine tool in academic research, for the development of functional foods and for clinical diagnostics. Lipidomics represents a quantitative phenotyping tool with incisive multi-parametric resolution. Personalized healthcare will be revolutionized by this new technology. Simply said, our vision and slogan is: Lipidomics for a better life!

Q: And what new does your company Lipotype offer?

Kai Simons: We want to enable every researcher to try out lipidomics. Thus, with several others, we introduced a very price-competitive package in our service portfolio of lipid analysis. With the minimum amount of 900 Euro a customer can get a basic analysis of 6 biological samples, what gives only 150 Euro per sample!

Q: What is unique about Lipotype lipid analysis services?

Kai Simons: Lipotype lipid analyses are high-throughput, with broad coverage of lipids and absolute quantitation of each lipid species. Recently, we published a joint paper with Nestlé Institute of Health Sciences, where we showed that the results generated with Lipotype technology are highly reproducible. We performed a comparison and showed that results obtained completely independently at different sites by different researchers have an average coefficient of variation of less than 15%.

The high quality standards of Lipotype are based on years of research experience from our work at Max-Planck on the role of lipids in cellular processes and on the development of lipidomics technology. We believe that the advantages of our technology are an essential prerequisite for the identification of statistical significant and clinical relevant lipid signatures, which can now be used by our customers.

Q: Lipotype will also introduce a webshop to sell its scientific services. That’s quite new for analytical services. Why did you decide to do that?

Kai Simons: Yes, we believe that introducing the webshop is totally novel in our market segment. The advantages will be obvious to our customers. The different service packages are grasped in a glance, prices are known from the beginning and in overall this provides a convenient way to purchase our services.


Please visit our webshop preview here
Learn more about our highlights here

Lipotype GmbH and Nestlé Institute of Health Sciences collaborate on lipidomics research

Press Release, Dresden, 07th October 2015

Lipotype GmbH, a Max-Planck spin-off company and the Nestlé Institute of Health Sciences (NIHS) collaborate to employ the innovative Lipotype Shotgun Lipidomics Technology to analyse lipids in blood for nutritional research. Recently, Lipotype and NIHS jointly published results of the robustness of the Lipotype Technology. Lipotype envisions a future use of its technology in clinical diagnostics screens for establishing reliable lipid diagnostic biomarkers.

 

Innovative Lipotype Technology for lipid analysis

The purpose of this collaboration is to enable NIHS to use the Lipotype Shotgun Lipidomics Technology for lipid analysis. The mass spectrometry-based Lipotype technology covers a broad spectrum of lipid molecules and delivers quantitative results in high-throughput. The Nestlé Institute of Health Sciences uses this technology platform for nutritional research. NIHS is a specialized biomedical research institute and is part of Nestlé’s global Research & Development network.

 

Joint research project reveals robustness of Lipotype Technology

During the collaboration, Lipotype and NIHS conducted a joint research project and demonstrated that the Lipotype technology was robust enough to deliver data with high precision and negligible technical variation between different sites.

 

Read the full press release here:

Download the Microsoft Word Version

Open Adobe PDF Document

 


 

Reference

A. Surma, R. Herzog, A. Vasilj, C. Klose, N. Christinat, D. Morin-Rivron, K. Simons, M. Masoodi, and J. L. Sampaio: “An Automated Shotgun Lipidomics Platform for High Throughput, Comprehensive, and Quantitative Analysis of Blood Plasma Intact Lipids.”

European Journal of Lipid Science and Technology (2015) Volume 117, Issue 10 (doi:10.1002/ejlt.201500145)
Media contact

Oliver Uecke
+49 (0) 351 79653-45
 media@lipotype.com
 www.lipotype.com

Lipotype GmbH
Tatzberg 47
01307 Dresden / Germany


 

About Lipotype

Lipotype is a spin-off company from the Kai Simons and Andrej Shevchenko labs of the world-renowned Max-Planck-Institute of Molecular Cell Biology and Genetics in Dresden, Germany. Drawing on many years of cutting edge research experience, Lipotype delivers comprehensive, absolutely quantitative lipid analysis services for clinical and biological samples on a high-throughput scale.

Lipotype offers high quality lipid analysis services for a wide range of customers and applications including biomarker identification for clinical researchers, pharma and biotech companies, functional food development for the food industry, as well as for the small-scale profiling needs of academic researchers.

Lipotype and Nestle Institute of Health Sciences publish paper about the Lipotype shotgun lipidomics platform

An automated shotgun lipidomics platform for high throughput, comprehensive,
and quantitative analysis of blood plasma intact lipids

Blood plasma has gained protagonism in lipidomics studies due to its availability, uncomplicated collection and preparation, and informative readout of physiological status. At the same time, it is also technically challenging to analyze due to its complex lipid composition affected by many factors, which can hamper the throughput and/or lipidomics coverage.

To tackle these issues, we developed a comprehensive, high throughput, and quantitative mass spectrometry-based shotgun lipidomics platform for blood plasma lipid analyses. The main hallmarks of this technology are (i) it is comprehensive, covering 22 quantifiable different lipid classes encompassing more than 200 lipid species; (ii) it is amenable to high-throughput, with less than 5min acquisition time allowing the complete analysis of 200 plasma samples per day; (iii) it achieves absolute quantification, by inclusion of internal standards for every lipid class measured; (iv) it is highly reproducible, achieving an average coefficient of variation of <10% (intra-day), approx. 10% (inter-day), and approx. 15% (inter-site) for most lipid species; (v) it is easily transferable allowing the direct comparison of data acquired in different sites.

Moreover, we thoroughly assessed the influence of blood stabilization with different anticoagulants and freeze-thaw cycles to exclude artifacts generated by sample preparation.

Access to the full paper

 


 

Reference

A. Surma, R. Herzog, A. Vasilj, C. Klose, N. Christinat, D. Morin-Rivron, K. Simons, M. Masoodi, and J. L. Sampaio: “An Automated Shotgun Lipidomics Platform for High Throughput, Comprehensive, and Quantitative Analysis of Blood Plasma Intact Lipids.”.
 European Journal of Lipid Science and Technology (2015) Volume 117, Issue 10 (doi:10.1002/ejlt.201500145)

Do you want to raft with us? – Meet us here…

 

Meet the LIPOTYPE team until the end of year at the following events:

1-2. October 2015
Bionection, Leipzig, Germany
Partnering Conference for Technology Transfer in Life Sciences. We attend, present details about our technology and applications as well are sponsors of this event.

 

6-8. October 2015
Biotechnica, Hannover, Germany
Europe’s No.1 Event for Biotechnology, Life Sciences and Lab Technology. Please visit our booth in Hall 9, Stand F14 and attend our talk “A ShotgunLipidomics Technology for the Identification of Biomarkers“ (Market place Personalized Medicine Technologies: Hall 9, Stand C55 on 6th October 2015; 16-16.30)

 

15-17. November 2015
Lipidomics Forum, Research Center Borstel, Germany
Kai Simons, CEO of Lipotype, gives the opening keynote, Ronny Herzog introduces latest developments of LipotypeXplorer for lipid identification and Lipotype is also the exlusive sponsor for the best young academics talk and poster prize.

 

1-2. December 2015
Join us and discuss about lipidomics during the poster session.

 

12-16. December 2015
ASCB annual meeting, San Diego, CA, US
Please visit our booth 1223 and attend our Exhibitor Tech Talk about “An automated shotgun lipidomics platform for high throughput, comprehensive, and quantitative analysis of lipids from biological and clinical samples” on 13.12.2015 at 9:50-10:10 am (Theater 1, Learning Center)