Bariatric surgery has been found to improve insulin sensitivity and release in diabetic patients, but the mechanisms behind it are not fully understood. In order to investigate these mechanisms, researchers used mass spectrometry to study changes in the lipidomic profile of skeletal muscle cells in six patients before and after biliopancreatic diversion.
They found that there was a decrease in lipid storage species, such as triacylglycerides, and an increase in structural and signaling lipids, including phosphatidylcholines, phosphatidylinositols, and cardiolipins. The increase in structural lipids was directly correlated with improved post-operative insulin sensitivity, while the decrease in triacylglycerides was inversely correlated with it.
In addition to other factors, the researchers suggest that this metabolic recovery of skeletal muscle cells may contribute to the short-term recovery of insulin sensitivity after biliopancreatic diversion.
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#lipotype #lipid #LipidMetabolism #lipidomics #InsulinSensitivity #diabetes #TeamMassSpec #MassSpectrometry #BariatricSurgery
