The enrichment of stearic- and arachidonic acids (38:4) in phosphoinositide lipids (PPIn) is established and maintained through the metabolic fate of newly synthesized phosphatidic acid (PA), which is the lipid precursor of phosphatidylinositol (PI).
A recent study shows that the fatty acyl-CoA used in the synthesis of PA affects the metabolic fate of PA with a preferential routing of the arachidonoyl-enriched species toward PI synthesis.
Additionally, the study found that during agonist stimulation, the unsaturated forms of PI(4,5P)2 are replenished faster than the more saturated ones, indicating favored recycling of the unsaturated forms of the PLC-generated hydrolytic products.
Read here the details:
#phosphoinositide #MassSpectrometry #TeamMassSpec #lipid #lipidomics #LipidMetabolism #PhosphatidicAcid #phosphatidylinositol
