Because of irresponsible antibiotic prescription and usage, some bacteria developed resistances to multiple antibiotics, while other bacteria are naturally multi resistant. According to the 2016 review on antimicrobial resistance by amr-review.org, multi resistant pathogens may become the leading cause of death by 2050.
Besides using antibiotics mindfully to slow down the adaption process of bacteria, and developing new antibiotics, scientists are increasingly exploring a third approach: they are looking for ways to make multi resistant bacteria susceptible to already existing antibiotics (again).
Breaking antimicrobial resistance mechanisms is a task easier said than done. Lipidomics analysis is helpful in this case. A global lipidomics analysis of P. aeruginosa revealed significant differences in lipids between the wildtype and the mutant strain, affecting the susceptibility of P. aeruginosa to many antibiotics.
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#MultiResistantBacteria #antibiotics #lipid #lipidomics #LipidMetabolism
