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Mannosyl-inositol-phosphoryl-ceramide

We provide MS-based lipid analysis of MIPC phosphosphingolipids in yeast samples and deliver results in as little as two weeks.

Details

About the structure and biological function of MIPC

Structure. Mannosyl-inositolphosphoryl-ceramides (mannose-inositol-P-ceramides, or MIPC) are a type of glycophospho-sphingolipids, a subclass of phosphosphingolipids. Their structure consists of a ceramide backbone bound to a mannosylated phosphorylinositol molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Mannosyl-inositolphosphoryl-ceramides are important components of biological membranes of fungi. Together with M(IP)2C, they constitute the major sphingolipids in yeasts, where they have multiple functions related to maintenance of cell morphology and are required for the localization of cell membrane proteins. Depending on the immune status of the host, MIPC ceramides of the pathogenic yeast candida albicans indirectly cause immune system disorder and persistent fungal disease.

GENERAL STRUCTURE
MIPC

General molecular structure of mannosyl-inositolphosphoryl-ceramide.

MIPC lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 50
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Yeast includes:
CDP-DAG, Erg, EE, IPC, MIPC, M(IP)2C

REPORTED AS
MIPC 46:0;3

An example for the molecular structure of mannosyl-inositolphosphoryl-ceramide, specifically MIPC 46:0;3.

GENERAL STRUCTURE
MIPC

General molecular structure of mannosyl-inositolphosphoryl-ceramide.

REPORTED AS
MIPC 42:0;3

An example for the molecular structure of mannosyl-inositolphosphoryl-ceramide, specifically MIPC 42:0;3.

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