About the structure and biological function of MIPC
Structure. Mannosyl-inositolphosphoryl-ceramides (mannose-inositol-P-ceramides, or MIPC) are a type of glycophospho-sphingolipids, a subclass of phosphosphingolipids. Their structure consists of a ceramide base bound to a mannosylated phosphorylinositol molecule. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
MIPC lipids are mainly found in fungi. On a subcellular level, they are enriched in the cell membrane.
Function. Mannosyl-inositolphosphoryl-ceramides are important components of biological membranes of fungi. Together with M(IP)2C, they constitute the major sphingolipids in yeasts, where they have multiple functions related to maintenance of cell morphology and are required for the localization of cell membrane proteins. Depending on the immune status of the host, MIPC ceramides of the pathogenic yeast candida albicans indirectly cause immune system disorder and persistent fungal disease.
MIPC lipidomics analysis with
|Structural details||species level|
|Variants identified||> 50|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-4 weeks|
|Lipidomics data||pmol & mol%|
Erg, EE, CDP-DAG, IPC, MIPC, M(IP)2C
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