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Mannosyl-di-(inositol-phosphoryl)-ceramide

We provide MS-based lipid analysis of M(IP)2C phosphosphingolipids in yeast samples and deliver results in as little as two weeks.

Details

About the structure and biological function of M(IP)2C

Structure. Mannosyl-di-(inositol-phosphoryl)-ceramides (mannose-(inositol-P)2-ceramides, or M(IP)2C) are a type of glycophosphosphingolipids, a subclass of phosphosphingolipids. Their structure consists of a ceramide base bound to two linked phosphorylinositol molecules of which one is mannosylated. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. Little is known about the biological function of mannosyl-di-(inositolphosphoryl)-ceramides but they are important components of biological membranes of fungi. Together with MIPC, they constitute the major sphingolipids in yeasts. As M(IP)2C lipids are not produced in mammals, targeting their synthesis is a strategy for novel antifungal drugs. Further, M(IP)2C ceramides interact with plant defensins, small peptides produced by plants that possess antifungal activity.

GENERAL STRUCTURE
M(IP)2C

General molecular structure of mannosyl-di-(inositolphosphoryl)-ceramide.

M(IP)2C lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 25
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Yeast includes:
Erg, EE, CDP-DAG, IPC, MIPC, M(IP)2C

REPORTED AS
M(IP)2C 43:0;3

An example for the molecular structure of mannosyl-di-(inositolphosphoryl)-ceramide, specifically M(IP)2C 43:0;3.

GENERAL STRUCTURE
M(IP)2C

General molecular structure of mannosyl-di-(inositolphosphoryl)-ceramide.

REPORTED AS
M(IP)2C 46:0;3

An example for the molecular structure of mannosyl-di-(inositolphosphoryl)-ceramide, specifically M(IP)2C 46:0;3.

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