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Lyso-phosphatidyl-serine

We provide MS-based lipid analysis of LPS phospholipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of LPS

Structure. Lyso-phosphatidyl-serines (LysoPtdSer, LysoPS, or LPS) are a type of glycerophosphoserines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphoserine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Lyso-phosphatidyl-serines are mediators in many biological processes, especially those of the immune system of animals. LPS levels are elevated by various inflammatory stimuli and after injury, where it can transmit the information to other cells. Thus they contribute to the resolution of inflammation. Yet, certain LPS lipids have pro-inflammatory reactions. Further, LPS metabolism aberrations are linked to cancers, night blindness, and PHARC, a genetic neurological disorder.

Related research

Cardiac Lipid Metabolism
Heart failure changes lipid metabolism in cardiac tissue of mice. The altered lipid profile can be confirmed in human plasma.
Read more

GENERAL STRUCTURE
LPS

General molecular structure of lyso-phosphatidylserine.

LPS lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 100
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer

REPORTED AS
LPS 16:1;0

An example for the molecular structure of lyso-phosphatidylserine, specifically LPS 16:1;0.

GENERAL STRUCTURE
LPS

General molecular structure of lyso-phosphatidylserine.

REPORTED AS
LPS 22:6;0

An example for the molecular structure of lyso-phosphatidylserine, specifically LPS 22:6;0.

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