About the structure and biological function of LPS
Structure. Lyso-phosphatidyl-serines (LysoPtdSer, LysoPS, or LPS) are a type of glycerophosphoserines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to a fatty acid and a phosphoserine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
LPS lipids are found in all organisms. On a subcellular level, they are enriched in the cell membrane.
Function. Lyso-phosphatidyl-serines are mediators in many biological processes, especially those of the immune system of animals. LPS levels are elevated by various inflammatory stimuli and after injury, where it can transmit the information to other cells. Thus they contribute to the resolution of inflammation. Yet, certain LPS lipids have pro-inflammatory reactions. Further, LPS metabolism aberrations are linked to cancers, night blindness, and PHARC, a genetic neurological disorder.
Cardiac Lipid Metabolism
Heart failure changes lipid metabolism in cardiac tissue of mice. The altered lipid profile can be confirmed in human plasma.
LPS lipidomics analysis with
|Structural details||species level|
|Variants identified||> 100|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
LPA, LPC, LPE, LPG, LPI, LPS, CL, PC O-, PE O-, LPC O-, LPE O-, Cer, HexCer
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