About the structure and biological function of IPC
Structure. Inositolphosphoryl-ceramides (inositol-P-ceramides, or IPC) are a type of phosphosphingolipids, a class of sphingolipids. Their structure consists of a ceramide backbone bound to a phosphorylinositol molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.
IPC lipids are found in many eukaryotes such as fungi and plants but not mammals. On a subcellular level, they are enriched in the cell membrane.
Function. Inositolphosphoryl-ceramides are substantial components of biological membranes in yeast. In lipid rafts of the cell membrane, IPC lipids interact with membrane proteins with signaling functions – a role similar to those of sphingomeylins in animals. IPC ceramides are also the precursor for further complex glycophosphosphingolipids. Further, the biosynthesis of IPC lipids reduces the pool of intracellular ceramide and thus inhibits programmed cell death.
IPC lipidomics analysis with
|Structural details||species level|
|Variants identified||> 50|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||2-4 weeks|
|Lipidomics data||pmol & mol%|
Erg, EE, CDP-DAG, IPC, MIPC, M(IP)2C
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