About the structure and biological function of IPC
Structure. Inositolphosphoryl-ceramides (inositol-P-ceramides, or IPC) are a type of phosphosphingolipids, a class of sphingolipids. Their structure consists of a ceramide base bound to a phosphorylinositol molecule. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
IPC lipids are found in many eukaryotes such as fungi and plants but not mammals. On a subcellular level, they are enriched in the cell membrane.
Function. Inositolphosphoryl-ceramides are substantial components of biological membranes in yeast. In lipid rafts of the cell membrane, IPC lipids interact with membrane proteins with signaling functions – a role similar to those of sphingomeylins in animals. IPC ceramides are also the precursor for further complex glycophosphosphingolipids. Further, the biosynthesis of IPC lipids reduces the pool of intracellular ceramide and thus inhibits programmed cell death.
IPC lipidomics analysis with
|Structural details||species level|
|Variants identified||> 50|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-4 weeks|
|Lipidomics data||pmol & mol%|
Erg, EE, CDP-DAG, IPC, MIPC, M(IP)2C
Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.
You want to inquire lipid analysis for your project or ask questions about Lipotype Shotgun Lipidomics? Please use the contact form below!