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Inositol-phosphoryl-ceramide

We provide MS-based lipid analysis of IPC phosphosphingolipids in yeast samples and deliver results in as little as two weeks.

Details

About the structure and biological function of IPC

Structure. Inositolphosphoryl-ceramides (inositol-P-ceramides, or IPC) are a type of phosphosphingolipids, a class of sphingolipids. Their structure consists of a ceramide backbone bound to a phosphorylinositol molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Inositolphosphoryl-ceramides are substantial components of biological membranes in yeast. In lipid rafts of the cell membrane, IPC lipids interact with membrane proteins with signaling functions – a role similar to those of sphingomeylins in animals. IPC ceramides are also the precursor for further complex glycophosphosphingolipids. Further, the biosynthesis of IPC lipids reduces the pool of intracellular ceramide and thus inhibits programmed cell death.

GENERAL STRUCTURE
IPC

General molecular structure of inositolphosphoryl-ceramide.

IPC lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 50
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Yeast includes:
CDP-DAG, Erg, EE, IPC, MIPC, M(IP)2C

REPORTED AS
IPC 40:0;3

An example for the molecular structure of inositolphosphoryl-ceramide, specifically IPC 40:0;3.

GENERAL STRUCTURE
IPC

General molecular structure of inositolphosphoryl-ceramide.

REPORTED AS
IPC 46:0;4

An example for the molecular structure of inositolphosphoryl-ceramide, specifically IPC 46:0;4.

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