About the structure and biological function of HexCer
Structure. Hexosylceramides (mono-hexosylceramides, monoglycosylceramides, cerebrosides, CerG1, or HexCer) are a type of glycosphingolipids. Their structure consists of a ceramide base linked to a neutral sugar molecule. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
Hexosylceramides are found mainly in eukaryotes. On a subcellular level, they are enriched in the cell membrane of animal nervous and plant photosynthetic tissue, and in the cell wall and membrane of fungi.
Function. Many hexosylceramides serve as key precursors for the biosynthesis of dihexosylceramides and thus for more complex glycosphingolipids such as globosides and gangliosides. Yet, they are vital to cell function, for example as structural components of cell membranes and lipid rafts. Hexosylceramides are critical to structure, function, and long-term stability of myelin, as well as for axonal growth of neurons. Further, some hexosylceramides are essential for preventing trans-epidermal water loss.
Neurons & Glia Cells
The brain of mammals is the second-most lipid-rich organ. Lipid analysis of neural cells helps understand its complex structure.
HexCer lipidomics analysis with
|Structural details||species level|
|Variants identified||> 100|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer
2Blood Extended includes:
PA, PG, LPA, LPI, LPC O-, LPE O-, HexCer
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