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Hexosyl-ceramide

We provide MS-based lipid analysis of HexCer glycosphingolipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of HexCer

Structure: Hexosylceramides (mono-hexosylceramides, monoglycosylceramides, cerebrosides, CerG1, or HexCer, glucosylceramide, galactosylceramide) are a type of glycosphingolipids. Their structure consists of a ceramide backbone linked to a neutral sugar molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function: Many hexosylceramides serve as key precursors for the biosynthesis of dihexosylceramides and thus for more complex glycosphingolipids such as globosides and gangliosides. Yet, they are vital to cell function, for example as structural components of cell membranes and lipid rafts. Hexosylceramides are critical to structure, function, and long-term stability of myelin, as well as for axonal growth of neurons. Further, some hexosylceramides are essential for preventing trans-epidermal water loss.

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GENERAL STRUCTURE
HexCer

General molecular structure of hexosylceramide.

HexCer lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 100
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
LPA, LPC, LPE, LPG, LPI, LPS, Cer, CL, PC O-, PE O-, LPC O-, LPE O-, HexCer

2Blood Extended includes:
PA, PG, LPA, LPI, LPC O-, LPE O-, HexCer

REPORTED AS
HexCer 40:2;3

An example for the molecular structure of hexosylceramide, specifically HexCer 40:2;3.

GENERAL STRUCTURE
HexCer

General molecular structure of hexosylceramide.

REPORTED AS
HexCer 30:1;2

An example for the molecular structure of hexosylceramide, specifically HexCer 30:1;2.

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