About the structure and biological function of Erg
Structure. Ergosterol (Erg) is a type of sterol lipid. Similar to cholesterol, the structure of ergosterol consists of four linked hydrocarbon rings, the steroid structure. A hydrocarbon tail is linked to one end of the steroid, a hydroxyl group linked to the other end. It contains no fatty acids.
Ergosterol is the major sterol lipid in fungi and also some unicellular eukaryotes. On a subcellular level, it is enriched in the cell membrane.
Function. Ergosterol serves an important structural role in the cell membrane of fungi and also forms lipid rafts – similar to cholesterol in animal cells. Under conditions of stress, the sterol concentration of the cell membrane can change rapidly. It also has multiple functions in growth regulation and is a precursor to vitamin D2. Further, a range of antifungal drugs targets ergosterol by either binding to it in the cell membrane to cause cellular leakage, or by preventing ergosterol synthesis.
Erg lipidomics analysis with
|Structural details||class level|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-4 weeks|
|Lipidomics data||pmol & mol%|
Erg, EE, CDP-DAG, IPC, MIPC, M(IP)2C
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