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CDP-diacylglycerol

We provide MS-based lipid analysis of CDP-DAG phospholipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of CDP-DAG

Structure. CDP-diacylglycerols (cytidine-diphosphate-diglycerides, CDP-diglycerides, or CDP-DAG) are a type of CDP-glycerols, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to two fatty acids and a cytidine diphosphate molecule (CDP). The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. CDP-DAG lipids occupy a branch point in the biosynthesis of complex glycerolipids. The distinct end-products depend on the subcellular location of synthesis. For example, CDP-DAGs are used for cardiolipin biosynthesis in mitochondria and for phosphatidylinositol and phosphatidylglycerol synthesis in the endoplasmic reticulum. Thus, CDP-DAG lipids also have a key role in regulation of phosphatidylinositol signal transduction. Further, they are linked to lipid droplet size in adipocytes.

GENERAL STRUCTURE
CDP-DAG

General molecular structure of CDP-diacylglycerol.

CDP-DAG lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified < 10
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Yeast includes:
CDP-DAG, Erg, EE, IPC, MIPC, M(IP)2C

REPORTED AS
CDP-DAG 34:1;0

An example for the molecular structure of CDP-diacylglycerol, specifically CDP-DAG 34:1;0.

GENERAL STRUCTURE
CDP-DAG

General molecular structure of CDP-diacylglycerol.

REPORTED AS
CDP-DAG 36:2;0

An example for the molecular structure of CDP-diacylglycerol, specifically CDP-DAG 36:2;0.

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