About the structure and biological function of CDP-DAG
Structure. CDP-diacylglycerols (cytidine-diphosphate-diglycerides, CDP-diglycerides, or CDP-DAG) are a type of CDP-glycerols, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to two fatty acids and a cytidine diphosphate molecule (CDP). The fatty acids can be of variable length, hydroxylated, and contain double bonds.
CDP-DAG lipids are found in eukaryotic and prokaryotic cells. On a subcellular level, they are enriched in the endoplasmic reticulum and in mitochondria.
Function. CDP-DAG lipids occupy a branch point in the biosynthesis of complex glycerolipids. The distinct end-products depend on the subcellular location of synthesis. For example, CDP-DAGs are used for cardiolipin biosynthesis in mitochondria and for phosphatidylinositol and phosphatidylglycerol synthesis in the endoplasmic reticulum. Thus, CDP-DAG lipids also have a key role in regulation of phosphatidylinositol signal transduction. Further, they are linked to lipid droplet size in adipocytes.
CDP-DAG lipidomics analysis with
|Structural details||species level|
|Variants identified||< 10|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-4 weeks|
|Lipidomics data||pmol & mol%|
Erg, EE, CDP-DAG, IPC, MIPC, M(IP)2C
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