Knowing the specific role of each gene, protein, or enzyme is essential to be able to use it in medical applications. This process is well-established and has been used to connect genes to proteins to particular metabolic conditions.

Using the CRISPR gene editing method, 23 genes involved in lipid metabolism were studied. This resulted in confirmation of the predicted roles for some genes, and the discovery of connections to certain lipid pathways for others. This study also allowed for the distinction of genes affecting mostly lipid classes, and others mainly affecting the fatty acid composition. The study carefully describes the role of each analyzed gene in the cell lipidome.

Scientists hope that this research will inspire more scientists to expand the screens to other cell lines, other genes of interest and additional pathways, incorporating the proteins involved at each different step of lipid metabolism.

Find out more: https://www.lipotype.com/lipidomics-resource-center/?q=set%20of%20gene%20knockouts

#lipid #metabolism #pathway #lipidomics #gene