Did you know that the metabolic fate of newly synthesized phosphatidic acid on its way to becoming phosphatidylinositol is influenced by the fatty acyl-CoA? Apparently, there is a preferential routing of the arachidonoyl-enriched species toward PI synthesis.
Additionally, utilization of fatty acyl-CoA for de novo phospholipid synthesis or lipid storage depends on the chain length and unsaturation.
This study shows how the unique fatty acyl side-chain profile of phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate is maintained during activation of phospholipase C and suggests that the metabolic fate of phosphatidic acid within the endoplasmic reticulum may be different depending on whether it is synthesized de novo or generated as the result of phospholipases C or D activation.
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#lipidomics #phospholipase #MassSpec #FattyAcyl #Metabolism #Lipid
