How is a protein TANGO2 regulating lipid metabolism in cells?
TANGO2 protein can be found in mitochondria, lipid droplets, and the endoplasmic reticulum. In a recent study, Lujan et al. demonstrated that cells lacking TANGO2 had enlarged lipid droplets and produced high levels of reactive oxygen species and lipid peroxidation due to a deficiency in acyl-CoA metabolism.

These findings shed light on the metabolic crises observed in TANGO2 mutation patients. Additionally, TANGO2 seems to be critical in producing specific phospholipids, and its deficiency affects the synthesis of mitochondria cardiolipin, contributing to metabolic crises.

The authors propose that B-complex and multivitamins could restore TANGO2 function, likely by stimulating new lipid biosynthesis and exerting antioxidant effects. This effect could have particular significance in starving cells that rely heavily on lipids for ATP production.
Check the link to the study to learn more: https://www.lipotype.com/lipidomics-resource-center/?q=Defects%20in%20lipid%20homeostasis%20reflect%20the%20function%20of%20TANGO2%20in%20phospholipid%20and%20neutral%20lipid%20metabolism

#LipidMetabolism #Phospholipids #MetabolicCrises #lipidomics #lipid #MassSpectrometry