Glycolysis and KRAS localization

Aerobic glycolysis is crucial for KRAS plasma membrane localization. A defined subset of glycosphingolipids, including GM3 and SM4, is required to maintain KRAS plasma membrane localization and its nanoscale spatial organization. Oncogenic KRAS selectively upregulates these same glycosphingolipids, and their depletion abrogates KRAS oncogenesis in pancreatic cancer models. The positive feedforward loop between oncogenic KRAS

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Aerobic glycolysis is crucial for KRAS plasma membrane localization. A defined subset of glycosphingolipids, including GM3 and SM4, is required to maintain KRAS plasma membrane localization and its nanoscale spatial organization.

Oncogenic KRAS selectively upregulates these same glycosphingolipids, and their depletion abrogates KRAS oncogenesis in pancreatic cancer models.

The positive feedforward loop between oncogenic KRAS signaling and glycosphingolipid synthesis represents a potential therapeutic target.

Read more here: https://www.lipotype.com/lipidomics-resource-center/?q=Glycolysis%20regulates%20KRAS%20plasma%20membrane%20localization

#glycolysis #KRAS #PlasmaMembrane #glycosphingolipid #lipid #lipidomics #MassSpectrometry

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