A recent study investigates the effect of a glycerol/petrolatum-based emollient (G/P-emollient) cream on the lipid profiles of the stratum corneum (SC) matrix, which is crucial for the skin barrier function. The study used various methods to analyze the spatial organization of the cream and the inter-bilayer distance in the multi-lamellar lipid structures and lattice type, and to quantify ceramide classes and chain lenghts.
The results indicate that the cream’s crystallized components are lipids, which were similar to the SC structure, and it penetrated the SC without altering its lamellar structure. The cream increased the amount of higher carbon number ceramides and decreased lower carbon number ceramides, as well as increased acyl-Cer classes and chain lengths.
The study suggests that G/P-emollient cream may be beneficial for skin pathologies by modifying SC lipids, balancing Cer levels and ratios, and improving the barrier function.
Learn more here:
#StratumCorneum #SkinLipidomics #lipid #LipidMetabolism #SkinLipids #SkinLipidMetabolism
