Dried Blood Spot (DBS) Lipidomics
We help you explore the lipid composition of your dried blood spot (DBS) samples.
The DBS Lipid Panel
Dried blood spot (DBS) Lipid Panel enables comprehensive lipid profiling from a minimally invasive sample collected by fingerprick onto filter paper. The dried matrix stabilizes lipids, and samples should be stored frozen prior to shipping, making DBS ideal for remote sampling, biobanking, and large-scale epidemiological studies with straightforward handling requirements. Lipids are extracted directly from the dried blood disc, capturing both plasma-derived and cellular lipid species from erythrocytes and other blood cells present in whole blood.
The lipid composition of DBS reflects the full cellular and circulatory lipid landscape, including phosphatidylserines and cardiolipins contributed by blood cells – species that may be underrepresented in plasma or serum alone. With Lipotype’s DBS lipidomics covering 24 lipid classes, compared to 16 in plasma, DBS provides a broader coverage of the lipidome, making it particularly powerful for capturing cell-associated lipid biology alongside circulating lipid species.
Dried blood spot (DBS) Lipid Panel supports in-depth analysis of lipid metabolism as reflected in dried blood spots. The expanded coverage of 24 lipid classes in DBS makes it especially suited for studies where a comprehensive lipid picture is critical, including research into autoimmune conditions, metabolic disorders, and hematological diseases. Cellular lipids such as phosphatidylserine and specific phosphatidylglycerols, associated with immune regulation and disease progression, are well-represented in the DBS matrix.
Dried blood spot (DBS) Lipid Panel is particularly effective for large-scale or decentralized studies, as the format supports self-sampling, frozen storage, and simplified shipping without compromising lipid integrity. It retains unique lipid species from erythrocytes and other blood cells that are typically marginal in plasma and serum. As a result, DBS lipidomics offers both logistical convenience and a richer, more complete perspective on lipid involvement in cellular and systemic biology.
Dried blood spot (DBS) Lipid Panel enables comprehensive lipid profiling from a minimally invasive sample collected by fingerprick onto filter paper. The dried matrix stabilizes lipids, and samples should be stored frozen prior to shipping, making DBS ideal for remote sampling, biobanking, and large-scale epidemiological studies with straightforward handling requirements. Lipids are extracted directly from the dried blood disc, capturing both plasma-derived and cellular lipid species from erythrocytes and other blood cells present in whole blood.
Dried blood spot (DBS) Lipid Panel supports in-depth analysis of lipid metabolism as reflected in dried blood spots. The expanded coverage of 24 lipid classes in DBS makes it especially suited for studies where a comprehensive lipid picture is critical, including research into autoimmune conditions, metabolic disorders, and hematological diseases. Cellular lipids such as phosphatidylserine and specific phosphatidylglycerols, associated with immune regulation and disease progression, are well-represented in the DBS matrix.
The lipid composition of DBS reflects the full cellular and circulatory lipid landscape, including phosphatidylserines and cardiolipins contributed by blood cells – species that may be underrepresented in plasma or serum alone. With Lipotype’s DBS lipidomics covering 24 lipid classes, compared to 16 in plasma, DBS provides a broader coverage of the lipidome, making it particularly powerful for capturing cell-associated lipid biology alongside circulating lipid species.
Dried blood spot (DBS) Lipid Panel is particularly effective for large-scale or decentralized studies, as the format supports self-sampling, frozen storage, and simplified shipping without compromising lipid integrity. It retains unique lipid species from erythrocytes and other blood cells that are typically marginal in plasma and serum. As a result, DBS lipidomics offers both logistical convenience and a richer, more complete perspective on lipid involvement in cellular and systemic biology.
FAQ
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Yes. Dried blood spots are a validated matrix for quantitative lipidomics. Lipotype’s proprietary sample preparation method is specifically developed and validated for DBS, delivering the same accurate quantification in pmol and mol% as plasma-based lipidomics.
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Yes – both partial and full method validation per ICH M10. Validation is documented in a Method Validation Plan (MVP) and results are reported in a Bioanalytical Report (BAR). Method validation is available as a standalone module or as part of a full GCP-compliant bioanalytical package.
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Contact us at service@lipotype.com to discuss your study requirements, sample numbers, compatible card types, and preparation guidelines before sending samples.
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Lipotype’s DBS Lipid Panel quantifies 24 lipid classes from a single dried blood spot, compared to 16 from plasma. This includes cardiolipins, phosphatidylserines, and phosphatidylglycerols and other lipid classes that are not accessible from plasma samples.
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DBS samples should be dried at room temperature and then stored frozen, ideally at -80°C, until analysis. While immediate cooling is not required at the moment of collection, cold storage is necessary to preserve lipid integrity prior to analysis.
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DBS sampling requires only a finger prick, with no phlebotomy and no anticoagulants. This makes it ideal for decentralised clinical trials, longitudinal studies with frequent sampling, and large-cohort research where participant burden and logistics need to be minimised.
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Dried blood spot (DBS) lipidomics is the quantitative analysis of lipids from a small blood sample collected via finger prick onto a filter card. Unlike plasma lipidomics, DBS captures the full whole-blood lipidome, including lipid classes from blood cell membranes and mitochondria.
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