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Sulfatide

We provide MS-based lipid analysis of Sulfatide in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of Sulfatide

Structure. Sulfatides (sulfated galactosyl-ceramides, sulfogalactosylceramides, galactosylceramide-sulfates, SO3-GalCer, or Sulf) are a type of sulfoglycolipids, a subclass of glycosphingolipids. Their structure consists of a ceramide base linked to a sulfated galactose sugar molecule. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. Sulfatides are a main constituent of myelin, the lipid coating around neuronal axons. Changes in brain sulfatide levels are linked to Alzheimer’s and Parkinson’s, and an abnormal sulfatide metabolism has been linked to cancers and autoimmune diseases. They also participate in many cellular processes from protein trafficking to signaling. Further, sulfatides are involved in the regulation of glucose uptake. Antibodies to sulfatides are often present in blood serum before the onset of diabetes.

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GENERAL STRUCTURE
Sulf

General molecular structure of sulfatide.

Sulf lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 50
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Sulf

REPORTED AS
Sulf 36:1;3

An example for the molecular structure of sulfatide, specifically Sulf 36:1;3.

GENERAL STRUCTURE
Sulf

General molecular structure of sulfatide.

REPORTED AS
Sulf 42:2;2

An example for the molecular structure of sulfatide, specifically Sulf 42:2;2.

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