Home   Lipidomics Analysis   SM Analysis 

Sphingomyelin

We provide MS-based lipid analysis of SM sphingolipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of SM

Structure. Sphingomyelins (CerPCho, or SM) are a type of phosphosphingolipids, a class of sphingolipids. Their structure consists of a ceramide backbone bound to a phosphorylcholine molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Sphingomyelins play a key role in the cell membrane of animals. They are vital to the formation of lipid rafts and required for the activity of raft-dependent membrane proteins such as some ion channels. They also serve as precursors for sphingolipids in the ‘sphingomyelin cycle’. Further, sphingomyelin metabolism aberrations have been linked to Alzheimer’s and cardiovascular disease.

Related research

Neurons & Glia Cells
The brain of mammals is the second-most lipid-rich organ. Lipid analysis of neural cells helps understand its complex structure.
Read more

GENERAL STRUCTURE
SM

General molecular structure of sphingomyelin.

SM lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 100
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Basic includes:
TAG, DAG, PA, PC, PE, PG, PI, PS, CE, SM

2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, Cer, Chol, CE, PC O-, PE O-, SM

REPORTED AS
SM 31:1;2

An example for the molecular structure of sphingomyelin, specifically SM 31:1;2.

GENERAL STRUCTURE
SM

General molecular structure of sphingomyelin.

REPORTED AS
SM 40:3;2

An example for the molecular structure of sphingomyelin, specifically SM 40:3;2.

About Lipotype

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Shotgun Lipidomics? Please use the contact form below!