About the structure and biological function of SM
Structure. Sphingomyelins (CerPCho, or SM) are a type of phosphosphingolipids, a class of sphingolipids. Their structure consists of a ceramide base bound to a phosphorylcholine molecule. The ceramide base contains two hydrocarbon chains, the fatty acid of the long-chain base and a second fatty acid. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
Sphingomyelins are found in all animal cells, blood plasma, and some protozoa. On a subcellular level, they are enriched in the cell membrane and in the nucleus membrane.
Function. Sphingomyelins play a key role in the cell membrane of animals. They are vital to the formation of lipid rafts and required for the activity of raft-dependent membrane proteins such as some ion channels. They also serve as precursors for sphingolipids in the ‘sphingomyelin cycle’. Further, sphingomyelin metabolism aberrations have been linked to Alzheimer’s and cardiovascular disease.
Neurons & Glia Cells
The brain of mammals is the second-most lipid-rich organ. Lipid analysis of neural cells helps understand its complex structure.
SM lipidomics analysis with
|Structural details||species level|
|Variants identified||> 100|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, PA, PC, PE, PG, PI, PS, CE, SM
2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, Cer, Chol, CE, PC O-, PE O-, SM
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