Non-hydroxy-6-hydroxysphingosine

We provide MS-based lipid analysis of NH ceramides in a variety of sample types and deliver results in as little as three weeks.

Details

Sphingolipids
Lipid Category

About the structure and biological function of NH

Structure. Non-hydroxy-fatty acid [N] 6-hydroxy-sphingosine [H] ceramides (CER[NH], or NH) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically 6-hydroxy-sphingosine, and a fatty acid, which is a non-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The biological role of non-hydroxy-6-hydroxy-sphingosines mainly revolves around skin health where they serve structural and signaling roles. NH ceramides contribute to epidermal barrier function which protects against environmental factors and prevents trans-epidermal water loss. Imbalanced skin ceramides can contribute or lead to the development of skin conditions. Further, NH ceramides are increased during winter months in healthy skin.

Non-hydroxy-6-hydroxysphingosine lipidomics analysis with Lipotype

Structural details
Variants identified
Approach
Method mass spectrometry
Device
Quantification yes
Delivery time
Lipidomics data pmol & mol%
Figuresyes
1Skin includes:
TAG, DAG, EOdS, EOS, EOP, EOH, NdS, NS, NP, NH, AdS, AS, AP, AH, Chol, CE

Example Structure
NH

An example for the molecular structure of non-hydroxy-6-hydroxy-sphingosine, specifically NH 18:1;3/21:0;0.

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