About the structure and biological function of PI
Structure. Phosphatidylinositols (PtdIns, GPIns, or PI) are a type of glycerophosphoinositols, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to two fatty acids and a phosphoinositol molecule. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
Phosphatidylinositols are mainly found in eukaryotic cells but elevated in animal brain tissue. On a subcellular level, they are enriched in biological membranes.
Function. Phosphatidylinositols are key membrane components and vital to many cellular processes. They are the major source for arachidonic acid for the synthesis of eicosanoids, bioactive lipids with signaling functions in allergy, inflammation, childbirth, pain perception, cell growth, blood pressure, and more. Further, phosphatidylinositols are the precursors to phosphoinositides with further signaling and other functional activities
Exosomes for Drug Delivery
Exosomes may be useful for targeted drug delivery. Proteomic & lipidomic characterization are required for this goal.
PI lipidomics analysis with
|Structural details||subspecies level|
|Variants identified||> 500|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, PA, PC, PE, PG, PI, PS, CE, SM
2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, Cer, Chol, CE, PC O-, PE O-, SM
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