About the structure and biological function of PE
Strutcure. Phosphatidylethanolamines (cephalins, PtdEtn, GPEtn, or PE) are a type of glycerophosphoethanolamines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to two fatty acids and a phosphoethanolamine molecule. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
Phosphatidylethanolamines are found in all organisms and each cell type. On a subcellular level, they are enriched in biological membranes.
Function. Phosphatidylethanolamines serve as key building blocks for biological membranes. They are vital for mitochondria functionality where they are synthesized from phosphatidylserine. Phosphatidylethanolamines interact with a wide range of proteins, thus influencing biological processes such as neuronal development or signaling pathways. Further, phosphatidylethanolamines are linked to plant embryo viability and plant pathogen resistance.
Cardiac Lipid Metabolism
Heart failure changes lipid metabolism in cardiac tissue of mice. The altered lipid profile can be confirmed in human plasma.
PE lipidomics analysis with
|Structural details||subspecies level|
|Variants identified||> 500|
|Device||Q Exactive Orbitrap (280.000 Res)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, PA, PC, PE, PG, PI, PS, CE, SM
2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, Cer, Chol, CE, PC O-, PE O-, SM
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