About the structure and biological function of PC
Structure. Phosphatidylcholines (lecithins, PtdCho, GPCho, or PC) are a type of glycerophosphocholines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to two fatty acids and a phosphocholine molecule. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
Phosphatidylcholines are mainly found in eukaryotes. On a subcellular level, they are enriched in cell membranes and in lipoprotein particles of blood plasma.
Function. Phosphatidylcholines serve as key building blocks for biological membranes, and they play an important role in plasma lipoproteins, the biochemical structures to transport lipids in blood plasma. Phosphatidylcholine is a precursor of acetylcholine, a neurotransmitter. Platelet-activating factor is a phosphatidylcholine. Phosphatidylcholines are elevated in cancers because of the increased demand for membrane constituents, and linked to liver conditions such as non-alcoholic fatty liver disease.
Neurons & Glia Cells
The brain of mammals is the second-most lipid-rich organ. Lipid analysis of neural cells helps understand its complex structure.
PC lipidomics analysis with
|Structural details||subspecies level|
|Variants identified||> 500|
|Method||mass spectrometry (untargeted)|
|Delivery time||2-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, PA, PC, PE, PG, PI, PS, CE, SM
2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, Cer, Chol, CE, PC O-, PE O-, SM
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