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Phosphatidyl-choline

We provide MS-based lipid analysis of PC phospholipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of PC

Structure. Phosphatidylcholines (lecithins, PtdCho, GPCho, or PC) are a type of glycerophosphocholines, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to two fatty acids and a phosphocholine molecule. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. Phosphatidylcholines serve as key building blocks for biological membranes, and they play an important role in plasma lipoproteins, the biochemical structures to transport lipids in blood plasma.  Phosphatidylcholine is a precursor of acetylcholine,  a neurotransmitter. Platelet-activating factor is a phosphatidylcholine. Phosphatidylcholines are elevated in cancers because of the increased demand for membrane constituents, and linked to liver conditions such as non-alcoholic fatty liver disease.

Related research

Breast Cancer & Lipid Metabolism
Breast cancer phospholipid metabolism is a powerful target for new therapies, especially against triple-negative breast cancer.
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GENERAL STRUCTURE
PC

General molecular structure of phosphatidylcholine.

PC lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 500
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Basic includes:
TAG, DAG, PA, PC, PE, PG, PI, PS, CE, SM

2Blood Basic includes:
TAG, DAG, PC, PE, PI, LPC, LPE, Cer, Chol, CE, PC O-, PE O-, SM

REPORTED AS
PC 12:0;0_16:1;0

An example for the molecular structure of phosphatidylcholine, specifically PC 12:0;0_16:1;0.

GENERAL STRUCTURE
PC

General molecular structure of phosphatidylcholine.

REPORTED AS
PC 18:0;0_22:5;0

An example for the molecular structure of phosphatidylcholine, specifically PC 18:0;0_22:5;0.

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