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Phosphatidate

We provide MS-based lipid analysis of PA phospholipids in a variety of sample types and deliver results in as little as two weeks.

Details

About the structure and biological function of PA

Structure. Phosphatidates (phosphatidic acids, PtdOH, or PA) are a type of glycerophosphates, a class of glycerophospholipids. Their structure consists of a glycerol backbone linked to two fatty acids and a phosphate group. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. Phosphatidates are key intermediates in the synthesis of other glycerophospholipids and triacylglycerols. Yet, phosphatidates modulate signaling and cellular processes such as vesicular trafficking, enzyme activity, as well as membrane structure and dynamics. They are activators of lipid-gated ion channels. They are also precursors of lyso-phosphatidates, which are key signaling molecules. Further, the reaction product of phosphatidates with ethanol is used as biomarker for alcohol consumption and they are the key plant lipid second messengers.

GENERAL STRUCTURE
PA

General molecular structure of phosphatidate.

PA lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 500
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Basic includes:
TAG, DAG, PA, PC, PE, PG, PI, PS, CE, SM

2Blood Extended includes:
PA, PG, LPA, LPI, LPC O-, LPE O-, HexCer

REPORTED AS
PA 18:2;0_20:2;0

An example for the molecular structure of phosphatidate, specifically PA 18:2;0_20:2;0.

GENERAL STRUCTURE
PA

General molecular structure of phosphatidate.

REPORTED AS
PA 16:0;0_18:0;0

An example for the molecular structure of phosphatidate, specifically PA 16:0;0_18:0;0.

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