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Omega-hydroxy-sphingosine

We provide MS-based lipid analysis of EOS skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.
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Details

About the structure and biological function of EOS

Structure. Omega-hydroxy-sphingosines (CER[EOS], or EOS) are a type of acylceramides, a subclass of ceramides. Their structure consists of a sphingoid base, specifically sphingosine, and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The biological function of omega-hydroxy-sphingosines is tightly linked to skin health where they serve mainly structural roles. EOS ceramides are important to the lamellar phase of the epidermal barrier function which prevents trans-epidermal water loss but also protects against environmental factors. Skin ceramide imbalances can lead or contribute to the development of skin conditions. Decreased EOS levels are associated with atopic dermatitis, psoriasis, and dry skin.

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GENERAL STRUCTURE
EOS

General molecular structure of omega-hydroxy-sphingosines.

EOS lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH

All lipid classes

TAG DAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS Cer CL Chol CE PC O- PE O- LPC O- LPE O- SM HexCer DiHexCer Gb3 Gb4 GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Sulf Erg EE CDP-DAG IPC MIPC M(IP)2C NdS NS NP NH AdS AS AP AH EOdS EOS EOP EOH

REPORTED AS
EOS 72:3;2

An example for the molecular structure of omega-hydroxy-sphingosines, specifically EOS 72:3;2.

GENERAL STRUCTURE
EOS

General molecular structure of omega-hydroxy-sphingosines.

REPORTED AS
EOS 65:3;2

An example for the molecular structure of omega-hydroxy-sphingosines, specifically EOS 65:3;2.

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