Home   Lipidomics Analysis   EOS Analysis 

Omega-hydroxy-sphingosine

We provide MS-based lipid analysis of EOS skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

About the structure and biological function of EOS

Structure. Omega-hydroxy-sphingosines (CER[EOS], or EOS) are a type of acylceramides, a subclass of ceramides. Their structure consists of a sphingoid base, specifically sphingosine, and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The biological function of omega-hydroxy-sphingosines is tightly linked to skin health where they serve mainly structural roles. EOS ceramides are important to the lamellar phase of the epidermal barrier function which prevents trans-epidermal water loss but also protects against environmental factors. Skin ceramide imbalances can lead or contribute to the development of skin conditions. Decreased EOS levels are associated with atopic dermatitis, psoriasis, and dry skin.

Related research

Moisturizer Research
Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
Read more

GENERAL STRUCTURE
EOS

General molecular structure of omega-hydroxy-sphingosines.

EOS lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH

REPORTED AS
EOS 72:3;2

An example for the molecular structure of omega-hydroxy-sphingosines, specifically EOS 72:3;2.

GENERAL STRUCTURE
EOS

General molecular structure of omega-hydroxy-sphingosines.

REPORTED AS
EOS 65:3;2

An example for the molecular structure of omega-hydroxy-sphingosines, specifically EOS 65:3;2.

About Lipotype

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Shotgun Lipidomics? Please use the contact form below!