About the structure and biological function of EOP
Structure. Omega-hydroxy-phyto-sphingosines (CER[EOP], or EOP) are a type of acylceramides, a subclass of ceramides. Their structure consists of a sphingoid base, specifically phytosphingosine, and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
Occurrence. Omega-hydroxy-phytosphingosines are found in skin. On a subcellular level, EOP lipids are enriched in the extracellular lipid matrix of the stratum corneum.
Function. The role of omega-hydroxy-phytosphingosines is mostly associated with human skin where they fulfill mainly structural purposes. EOP ceramides are relevant to the formation of the lamellar phase of the epidermal barrier to prevent trans-epidermal water loss but also protect against the environment. Skin ceramide profile aberrations can lead or contribute to skin conditions. In general, reduced levels of omega-hydroxy ceramides are linked to dry skin and psoriasis.
Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
EOP lipidomics analysis with
|Structural details||species level|
|Variants identified||> 10|
|Method||mass spectrometry (untargeted)|
|Delivery time||3-6 weeks|
|Lipidomics data||pmol & mol%|
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH
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