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Omega-hydroxy-phyto-sphingosine

We provide MS-based lipid analysis of EOP skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

About the structure and biological function of EOP

Structure. Omega-hydroxy-phyto-sphingosines (CER[EOP], or EOP) are a type of acylceramides, a subclass of ceramides. Their structure consists of a sphingoid base, specifically phytosphingosine, and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The role of omega-hydroxy-phytosphingosines is mostly associated with human skin where they fulfill mainly structural purposes. EOP ceramides are relevant to the formation of the lamellar phase of the epidermal barrier to prevent trans-epidermal water loss but also protect against the environment. Skin ceramide profile aberrations can lead or contribute to skin conditions.  In general, reduced levels of omega-hydroxy ceramides are linked to dry skin and psoriasis.

Related research

Moisturizer Research
Skin biology is central to develop reliable moisturizers, but molecular analysis of the skin has been lacking.
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GENERAL STRUCTURE
EOP

General molecular structure of omega-hydroxy-phytosphingosines.

EOP lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH

REPORTED AS
EOP 68:2;3

An example for the molecular structure of omega-hydroxy-phytosphingosines, specifically EOP 68:2;3.

GENERAL STRUCTURE
EOP

General molecular structure of omega-hydroxy-phytosphingosines.

REPORTED AS
EOP 72:2;3

An example for the molecular structure of omega-hydroxy-phytosphingosines, specifically EOP 72:2;3.

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