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Omega-hydroxy-6-hydroxy-sphingosine

We provide MS-based lipid analysis of EOH skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

About the structure and biological function of EOH

Structure. Omega-hydroxy-6-hydroxy-sphingosines (CER[EOH], or EOH) are a type of acylceramides, a subclass of ceramides. Their structure consists of a sphingoid base, specifically 6-hydroxy-sphingosine, and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Omega-hydroxy-6-hydroxy-sphingosines are mostly important for human skin where they serve mainly structural roles. EOH ceramides are critical to the lamellar phase of the epidermal barrier function to prevent trans-epidermal water loss but also protect against the environment. Aberrations of skin ceramide levels can contribute or lead to skin conditions. Reduced levels of EOH ceramides are linked to psoriasis and dry skin. Further, EOH lipids are increased in Albino African skin.

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GENERAL STRUCTURE
EOH

General molecular structure of omega-hydroxy-6-hydroxy-sphingosines.

EOH lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Methodmass spectrometry (untargeted)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, Chol, CE, NdS, NS, NP, NH, AdS, AS, AP, AH, EOdS, EOS, EOP, EOH

REPORTED AS
EOH 68:3;3

An example for the molecular structure of omega-hydroxy-6-hydroxy-sphingosines, specifically EOH 68:3;3.

GENERAL STRUCTURE
EOH

General molecular structure of omega-hydroxy-6-hydroxy-sphingosines.

REPORTED AS
EOH 66:3;3

An example for the molecular structure of omega-hydroxy-6-hydroxy-sphingosines, specifically EOH 66:3;3.

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